Methotrexate Other names: Amethopterin 4-amino-10-methylfolic acid

Chemical formula: C₂₀H₂₂N₈O₅  Molecular mass: 454.439 g/mol  PubChem compound: 126941

Therapeutic indications

Methotrexate is indicated for:

Acute leukemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Acute leukemia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Choriocarcinoma, trophoblastic diseases

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of
Choriocarcinoma
Gestational trophoblastic disease

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Psoriasis

Population group: only adults (18 years old or older)

Severe recalcitrant disabling psoriasis, which is not adequately responsive to other forms of therapy such as phototherapy, PUVA, and retinoids, and severe psoriatic arthritis in adult patients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Rheumatoid arthritis

Population group: only adults (18 years old or older)

Active rheumatoid arthritis in adult patients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Breast carcinoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

CA - Carcinoma of breast

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Meningeal leukaemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Meningeal leukemia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Burkitt's tumour

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Burkitt's lymphoma (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Mycosis fungoides

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Mycosis fungoides (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Methotrexate is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Significantly impaired hepatic function

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Alcoholism

Alcoholism

Significantly impaired renal function

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Bone marrow hypoplasia

Hypocellular bone marrow

Leukopenia

at least one of
Leukopenia
Decreased blood leukocyte number

Thrombocytopenia

Thrombocytopenic disorder

Anaemia

Anemia

Infections

Infectious disease

Immunodeficiency

Disorder of immune structure

Live vaccines

at least one of
Measles, combinations with mumps and rubella, live attenuated
Measles, combinations with mumps, live attenuated
Measles, combinations with mumps, rubella and varicella, live attenuated
Measles, combinations with rubella, live attenuated
Measles, live attenuated
Mumps, live attenuated
Poliomyelitis oral, monovalent live attenuated
Poliomyelitis oral, trivalent, live attenuated
Rota virus, live attenuated
Rota virus, pentavalent, live, reassorted
Rubella, combinations with mumps, live attenuated
Rubella, live attenuated
Tuberculosis, live attenuated
Typhoid, oral, live attenuated
Varicella, live attenuated
Yellow fever, live attenuated
Zoster, live attenuated

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