Prevention of atherothrombotic and thromboembolic events in atrial fibrillation

Active Ingredient: Clopidogrel

Indication for Clopidogrel

Population group: only adults (18 years old or older)
Therapeutic intent: Preventive action

In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists (VKA) and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke.

For this indication, competent medicine agencies globally authorize below treatments:

75 mg once a day

For:

Dosage regimens

Oral, 75 milligrams clopidogrel, once daily.

Detailed description

In patients with atrial fibrillation, clopidogrel should be given as a single daily dose of 75 mg. ASA (75-100 mg daily) should be initiated and continued in combination with clopidogrel.

If a dose is missed:

  • Within less than 12 hours after regular scheduled time: patients should take the dose immediately and then take the next dose at the regular scheduled time.
  • For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.

Active ingredient

Clopidogrel

Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation.

Read more about Clopidogrel

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