Osteoporosis

Active Ingredient: Abaloparatide

Indication for Abaloparatide

Population group: women, only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of osteoporosis in postmenopausal women at increased risk of fracture.

For this indication, competent medicine agencies globally authorize below treatments:

80 ug once daily for up to 18 months

For:

Dosage regimens

Subcutaneous, 80 micrograms abaloparatide, once daily, over the duration of 18 months.

Detailed description

The recommended dose is 80 micrograms once daily.

The maximum total duration of treatment with abaloparatide should be 18 months.

Patients should receive supplemental calcium and vitamin D if dietary intake is inadequate.

Following cessation of abaloparatide therapy, patients may be continued on other osteoporosis therapies such as bisphosphonates.

Missed dose

If a patient forgets or cannot administer their dose at the usual time, it can be injected within 12 hours of the normally scheduled time. Patients should not administer more than one injection in the same day and should not try to make up for a missed dose.

Dosage considerations

Abaloparatide should be injected in the lower abdomen. The site of the injection should be rotated every day. Injections should be administered at approximately the same time every day.

Active ingredient

Abaloparatide

Abaloparatide is a 34 amino acid peptide that shares 41% homology to parathyroid hormone [PTH] and 76% homology to parathyroid hormone related peptide [PTHrP(1-34)], and is an activator of the PTH1 receptor signalling pathway. Abaloparatide stimulates new bone formation on trabecular and cortical bone surfaces by stimulation of osteoblastic activity. Abaloparatide causes transient and limited increases in bone resorption and increases bone density.

Read more about Abaloparatide

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