PubChem compound: 145705876
Abaloparatide is a 34 amino acid peptide that shares 41% homology to parathyroid hormone [PTH] and 76% homology to parathyroid hormone related peptide [PTHrP(1-34)], and is an activator of the PTH1 receptor signalling pathway. Abaloparatide stimulates new bone formation on trabecular and cortical bone surfaces by stimulation of osteoblastic activity. Abaloparatide causes transient and limited increases in bone resorption and increases bone density.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
|H Systemic hormonal preparations, excl. Sex hormones and insulins → H05 Calcium homeostasis → H05A Parathyroid hormones and analogues → H05AA Parathyroid hormones and analogues
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
|ELADYNOS Solution for injection
|European Medicines Agency (EU)
|MPI, EU: SmPC
|TYMLOS Solution for injection
|FDA, National Drug Code (US)
|MPI, US: SPL/PLR
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