Active Ingredient: Calcitonin
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, between 100 international units calcitonin and 400 international units calcitonin, 3 to 4 times daily.
The recommended starting dose is 100 IU every 6 to 8 hours. If the response is not satisfactory after one or two days, the dose may be increased to a maximum of 400 IU every 6 to 8 hours.
As salmon calcitonin is a peptide, adsorption onto the plastic of the infusion set may occur. This has the potential to reduce the total dose delivered to the patient. Frequent monitoring of the clinical and laboratory response including the measurement of serum calcium is recommended especially in the early phases of treatment. The dosing of calcitonin should be individualized to the patient’s specific requirements.
For:
Regimen A: Intramuscular, between 100 international units calcitonin and 400 international units calcitonin, 3 to 4 times daily.
Regimen B: Subcutaneous, between 100 international units calcitonin and 400 international units calcitonin, 3 to 4 times daily.
Regimen C: Intravenous, between 100 international units calcitonin and 400 international units calcitonin, 3 to 4 times daily.
Regimen D: Intravenous, 10 international units calcitonin per kilogram of body weight, one dose.
The recommended starting dose is 100 IU every 6 to 8 hours by subcutaneous or intramuscular injection. In addition, salmon calcitonin could be administered by intravenous injection after previous rehydration.
If the response is not satisfactory after one or two days, the dose may be increased to a maximum of 400 IU every 6 to 8 hours. In severe or emergency cases, intravenous infusion with up to 10 IU/kg body weight in 500ml 0.9% w/v sodium chloride solution may be administered over a period of at least 6 hours.
As salmon calcitonin is a peptide, adsorption onto the plastic of the infusion set may occur. This has the potential to reduce the total dose delivered to the patient. Frequent monitoring of the clinical and laboratory response including the measurement of serum calcium is recommended especially in the early phases of treatment. The dosing of calcitonin should be individualized to the patient’s specific requirements.
For:
Nasal, 100 international units calcitonin, 2 to 4 times daily.
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