Renal disease in patients with diabetes and microalbuminuria

Active Ingredient: Ramipril

Indication for Ramipril

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Incipient glomerular diabetic nephropathy as defined by the presence of microalbuminuria.

For this indication, competent medicine agencies globally authorize below treatments:

1.25 once daily that can be progressively doubled at 2 week intervals to a maximum dose of 5 mg once daily


Dosage regimens

Oral, 1.25 milligrams ramipril, once daily, over the duration of 2 weeks. Afterwards, oral, between 1.25 milligrams ramipril and 5 milligrams ramipril, once daily. The maximum allowed total dose is 5 milligrams ramipril daily.

Detailed description

Starting dose:

The recommended initial dose is 1.25 mg of ramipril once daily.

Titration and maintenance dose:

Depending on the patient’s tolerability to the active substance, the dose is subsequently increased. Doubling the once daily dose to 2.5 mg after two weeks and then to 5 mg after a further two weeks is recommended.

Dosage considerations

It is recommended that ramipril is taken each day at the same time of the day.

Ramipril can be taken before, with or after meals, because food intake does not modify its bioavailability.

Active ingredient


Ramiprilat, the active metabolite of the prodrug ramipril, inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II). In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin. Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation.

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