Ramipril

Chemical formula: C₂₃H₃₂N₂O₅  Molecular mass: 416.511 g/mol  PubChem compound: 5362129

Active ingredient description

Ramiprilat, the active metabolite of the prodrug ramipril, inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II). In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin. Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C09AA05 Ramipril C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain
Discover more medicines within C09AA05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ALTACE Capsule FDA, National Drug Code (US) MPI, US: SPL/PLR
RAMIPRIL Capsule, hard Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 87333-19-5
DrugBank Drug: DB00178
KEGG Drug: D00421
PubChem Compound: 5362129
RxNorm Ingredient: 35296
SNOMED-CT Concept: 386872004
Ramipril (substance)
UNII Identifier: L35JN3I7SJ
RAMIPRIL

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