Mild to moderately severe dementia of the Alzheimer type

Active Ingredient: Galantamine

Indication for Galantamine

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Symptomatic treatment of mild to moderately severe dementia of the Alzheimer type.

For this indication, competent medicine agencies globally authorize below treatments:

8 mg once daily for 4 weeks and thereafter 16-24 mg once daily

Dosage regimens

Oral, 8 milligrams galantamine, once daily to breakfast, over the duration of 4 weeks. Afterwards, oral, between 16 milligrams galantamine and 24 milligrams galantamine, once daily to breakfast. The maximum allowed total dose is 24 milligrams galantamine daily.

Detailed description

Starting dose

The recommended starting dose is 8 mg/day for 4 weeks.

Maintenance dose

The tolerance and dosing of galantamine should be reassessed on a regular basis, preferably within 3 months after start of treatment. Thereafter, the clinical benefit of galantamine and the patient’s tolerance of treatment should be reassessed on a regular basis according to current clinical guidelines. Maintenance treatment can be continued for as long as therapeutic benefit is favourable and the patient tolerates treatment with galantamine. Discontinuation of galantamine should be considered when evidence of a therapeutic effect is no longer present or if the patient does not tolerate treatment.

The initial maintenance dose is 16 mg/day and patients should be maintained on 16 mg/day for at least 4 weeks.

An increase to the maintenance dose of 24 mg/day should be considered on an individual basis after appropriate assessment including evaluation of clinical benefit and tolerability.

In individual patients not showing an increased response or not tolerating 24 mg/day, a dose reduction to 16 mg/day should be considered.

Dosage considerations

It should be administered orally, once daily in the morning, preferably with food. Adequate fluid intake during treatment should be ensured.

Active ingredient


Galantamine, a tertiary alkaloid is a selective, competitive and reversible inhibitor of acetylcholinesterase. In addition, galantamine enhances the intrinsic action of acetylcholine on nicotinic receptors, probably through binding to an allosteric site of the receptor. As a consequence, an increased activity in the cholinergic system associated with improved cognitive function can be achieved in patients with dementia of the Alzheimer type.

Read more about Galantamine

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