For this indication, competent medicine agencies globally authorize below treatments:
For: Children Adolescents Adults (18-64)
Sublingual, 60 micrograms, 3 times daily. Afterwards, sublingual, between 60 and 120 micrograms, 3 times daily. The maximum allowed total dose is 720 micrograms daily.
Dosage is individual in diabetes insipidus but the total daily sublingual dose normally lies in the range of 120 micrograms to 720 micrograms.
A suitable starting dose in adults and children is 60 micrograms three times daily, administered sublingually. This dosage regimen should then be adjusted in accordance with the patient’s response. For the majority of patients, the maintenance dose is 60 micrograms to 120 micrograms sublingually three times daily.
For: Children Adolescents
Intrasinal, between 5 and 10 micrograms, divided 1 to 2 times daily. The maximum allowed total dose is 20 micrograms daily.
| Daily dose | |
|---|---|
| Children and Adolescents <18 years: | 5-10 micrograms |
In case of insufficient efficacy the dose can be increased on a case by case basis up to 20 µg in children and adolescents (<18 years) divided into 2 doses of 10 µg (1 spray in the morning and at bedtime).
The optimal dosage of desmopressin must be established individually and should be based on measurements of urine volume and osmolality. The treatment should aim at two goals: a normal water balance and an adequate duration of sleep (as a result of the improvement in the nocturia and nocturnal enuresis often observed in central diabetes insipidus). The goal of 6 to 7 dry nights/week should be achieved.
For: Adults (18-64)
Regimen A: Subcutaneous, between 1 and 4 micrograms, once daily.
Regimen B: Intramuscular, between 1 and 4 micrograms, once daily.
Regimen C: Intravenous, between 1 and 4 micrograms, once daily.
The usual dose is 1 to 4 micrograms given once daily.
For: Infants Children
Regimen A: Subcutaneous, 0.4 micrograms, once daily.
Regimen B: Intramuscular, 0.4 micrograms, once daily.
Regimen C: Intravenous, 0.4 micrograms, once daily.
Doses from 0.4 micrograms (0.1ml) may be used.