Cranial diabetes insipidus

Indication for Desmopressin

Population group: Suitable for both men and women, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

60 ug 3 times daily and thereafter 60-120 ug 3 times daily

For: Children Adolescents Adults (18-64)

Dosage regimens

Sublingual, 60 micrograms, 3 times daily. Afterwards, sublingual, between 60 and 120 micrograms, 3 times daily. The maximum allowed total dose is 720 micrograms daily.

Detailed description

Dosage is individual in diabetes insipidus but the total daily sublingual dose normally lies in the range of 120 micrograms to 720 micrograms.

A suitable starting dose in adults and children is 60 micrograms three times daily, administered sublingually. This dosage regimen should then be adjusted in accordance with the patient’s response. For the majority of patients, the maintenance dose is 60 micrograms to 120 micrograms sublingually three times daily.

5-10 ug daily

For: Children Adolescents

Dosage regimens

Intrasinal, between 5 and 10 micrograms, divided 1 to 2 times daily. The maximum allowed total dose is 20 micrograms daily.

Detailed description

 Daily dose
Children and Adolescents <18 years:5-10 micrograms

In case of insufficient efficacy the dose can be increased on a case by case basis up to 20 ยตg in children and adolescents (<18 years) divided into 2 doses of 10 ยตg (1 spray in the morning and at bedtime).

The optimal dosage of desmopressin must be established individually and should be based on measurements of urine volume and osmolality. The treatment should aim at two goals: a normal water balance and an adequate duration of sleep (as a result of the improvement in the nocturia and nocturnal enuresis often observed in central diabetes insipidus). The goal of 6 to 7 dry nights/week should be achieved.

1-4 ug once daily

For: Adults (18-64)

Dosage regimens

Regimen A: Subcutaneous, between 1 and 4 micrograms, once daily.

Regimen B: Intramuscular, between 1 and 4 micrograms, once daily.

Regimen C: Intravenous, between 1 and 4 micrograms, once daily.

Detailed description

The usual dose is 1 to 4 micrograms given once daily.

0.4 ug once daily

For: Infants Children

Dosage regimens

Regimen A: Subcutaneous, 0.4 micrograms, once daily.

Regimen B: Intramuscular, 0.4 micrograms, once daily.

Regimen C: Intravenous, 0.4 micrograms, once daily.

Detailed description

Doses from 0.4 micrograms (0.1ml) may be used.

Active ingredient

Desmopressin is a structural analogue of vasopressin in which the antidiuretic activity has been enhanced by the order of 10, while the vasopressor effect has been reduced by the order of 1500. The clinical advantage of this highly changed ratio of antidiuretic to vasopressor effect is that clinically active antidiuretic doses are far below the threshold for a vasopressor effect.

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