Active Ingredient: Desmopressin
For this indication, competent medicine agencies globally authorize below treatments:
For:
Sublingual, 60 micrograms desmopressin, 3 times daily. Afterwards, sublingual, between 60 micrograms desmopressin and 120 micrograms desmopressin, 3 times daily. The maximum allowed total dose is 720 micrograms desmopressin daily.
Dosage is individual in diabetes insipidus but the total daily sublingual dose normally lies in the range of 120 micrograms to 720 micrograms.
A suitable starting dose in adults and children is 60 micrograms three times daily, administered sublingually. This dosage regimen should then be adjusted in accordance with the patient’s response. For the majority of patients, the maintenance dose is 60 micrograms to 120 micrograms sublingually three times daily.
For:
Intrasinal, between 5 micrograms desmopressin and 10 micrograms desmopressin, divided 1 to 2 times daily. The maximum allowed total dose is 20 micrograms desmopressin daily.
| Daily dose | |
|---|---|
| Children and Adolescents <18 years: | 5-10 micrograms |
In case of insufficient efficacy the dose can be increased on a case by case basis up to 20 µg in children and adolescents (<18 years) divided into 2 doses of 10 µg (1 spray in the morning and at bedtime).
The optimal dosage of desmopressin must be established individually and should be based on measurements of urine volume and osmolality. The treatment should aim at two goals: a normal water balance and an adequate duration of sleep (as a result of the improvement in the nocturia and nocturnal enuresis often observed in central diabetes insipidus). The goal of 6 to 7 dry nights/week should be achieved.
For:
Regimen A: Subcutaneous, between 1 micrograms desmopressin and 4 micrograms desmopressin, once daily.
Regimen B: Intramuscular, between 1 micrograms desmopressin and 4 micrograms desmopressin, once daily.
Regimen C: Intravenous, between 1 micrograms desmopressin and 4 micrograms desmopressin, once daily.
The usual dose is 1 to 4 micrograms given once daily.
For:
Regimen A: Subcutaneous, 0.4 micrograms desmopressin, once daily.
Regimen B: Intramuscular, 0.4 micrograms desmopressin, once daily.
Regimen C: Intravenous, 0.4 micrograms desmopressin, once daily.
Doses from 0.4 micrograms (0.1ml) may be used.
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