Active Ingredient: Spironolactone
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A :
Oral, 400 milligrams spironolactone, once daily to meals, over the duration of 3 to 4 weeks.
Regimen B :
Oral, 400 milligrams spironolactone, once daily to meals, over the duration of 4 days.
Spironolactone may be employed as an initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets.
Long test: Spironolactone is administered at a daily dose of 400 mg for 3 to 4 weeks. Correction of hypokalaemia and of hypertension provides presumptive evidence for the diagnosis of primary hyperaldosteronism.
Short test: Spironolactone is administered at a daily dose of 400 mg for 4 days. If serum potassium increases during spironolactone administration but drops when spironolactone is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered.
Spironolactone should be taken together with a meal.
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