Cilazapril is indicated for the treatment of hypertension.
For this indication, competent medicine agencies globally authorize below treatments:
0.5 - 5 mg
From 0.5 To 5 mg once every day
The initial dose is 1 mg/day. Blood pressure should be assessed, and dosage adjusted individually in accordance with the blood pressure response. The usual dose range of cilazapril is 2.5 to 5.0 mg once daily.
Patients with a strongly activated renin-angiotensin-aldosterone system (in particular, salt and/or volume depletion, cardiac decompensation or severe hypertension) may experience an excessive drop in blood pressure following the initial dose. A lower starting dose of 0.5 mg once daily is recommended in such patients and the initiation of treatment should take place under medical supervision.
If possible, the diuretic should be discontinued 2-3 days before beginning therapy with cilazapril to reduce the likelihood of symptomatic hypotension. It may be resumed later if required. The recommended starting dose in these patients is 0.5 mg once daily.
As food intake has no clinically significant influence on absorption, cilazapril can be administered before or after a meal. The dose should always be taken at about the same time of day.