Neurogenic detrusor overactivity

Active Ingredient: Solifenacin

Indication for Solifenacin

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

For this indication, competent medicine agencies globally authorize below treatments:

1.5-10 mg once a day

Route of admnistration

Oral

Defined daily dose

1.5 - 10 mg

Dosage regimen

From 1.5 To 10 mg once every day

Loading dose

1.5 mg

Detailed description

The recommended dose of solifenacin is determined based on patient weight. Treatment should be initiated at the recommended starting dose. Thereafter, the dose may be increased to the lowest effective dose. The maximum dose should not be exceeded. During long-term therapy, patients should be periodically evaluated for treatment continuation and for potential dose adjustment, at least annually or more frequently if indicated.

Weight range (kg) Starting dose (ml)ยง1 Maximum dose (ml)ยง2
9 to 1524
>15 to 3035
>30 to 4536
>45 to 6048
>60510

ยง The oral suspension formulation of Vesicare has a concentration of 1 mg/ml.
1 Equivalent to steady-state exposure after a 5 mg daily dose in adults.
2 Equivalent to steady-state exposure after a 10 mg daily dose in adults.

Dosage considerations

It should be taken orally followed by a glass of water. It should not be ingested together with food and/or other drinks. This ingestion with food and/or drinks may cause a release of solifenacin in the mouth resulting in a bitter taste and a feeling of numbness in the mouth.

Active ingredient

Solifenacin

Solifenacin is a competitive, specific cholinergic-receptor antagonist. In vitro and in vivo pharmacological studies indicate that solifenacin is a competitive inhibitor of the muscarinic M3 subtype receptor.

Read more about Solifenacin

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