Active Ingredient: Paclitaxel
Paclitaxel monotherapy is indicated for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline containing therapy is not indicated.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 260 milligrams paclitaxel per square meter of body surface, once every 3 weeks.
The recommended dose of paclitaxel is 260 mg/m² administered intravenously over 30 minutes every 3 weeks.
Patients who experience severe neutropenia (neutrophil count <500 cells/mm³ for a week or longer) or severe sensory neuropathy during paclitaxel therapy should have the dose reduced to 220 mg/m² for subsequent courses. Following recurrence of severe neutropenia or severe sensory neuropathy, additional dose reduction should be made to 180 mg/m². Paclitaxel should not be administered until neutrophil counts recover to >1500 cells/mm³. For Grade 3 sensory neuropathy, withhold treatment until resolution to Grade 1 or 2, followed by a dose reduction for all subsequent courses.
Administered intravenously over 30 minutes every 3 weeks.
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