Stage III (Dukes' stage C) colon cancer after surgery - monotherapy

Active Ingredient: Capecitabine

Indication for Capecitabine

Population group: only adults (18 years old or older)
Therapeutic intent: Adjuvant - intent

Capecitabine is indicated for the treatment of for the adjuvant treatment of patients following surgery of stage III (Dukes' stage C) colon cancer.

For this indication, competent medicine agencies globally authorize below treatments:

1,250 mg/m² twice daily for 14 days followed by a 7-day rest period, for a total of 6 months

For:

Dosage regimens

Oral, 1,250 milligrams capecitabine per square meter of body surface, 2 times daily, 28 doses in total, over the duration of 21 days. This step is repeated 1 to 8 times.

Detailed description

Given as monotherapy, the recommended starting dose for capecitabine in the adjuvant treatment of colon cancer is 1250 mg/m² administered twice daily (morning and evening; equivalent to 2500 mg/m² total daily dose) for 14 days followed by a 7-day rest period. Adjuvant treatment in patients with stage III colon cancer is recommended for a total of 6 months.

Dosage considerations

It should be taken with water within 30 minutes after a meal.

Active ingredient

Capecitabine

Capecitabine is a non-cytotoxic fluoropyrimidine carbamate, which functions as an orally administered precursor of the cytotoxic moiety 5-fluorouracil (5-FU). Capecitabine is activated via several enzymatic steps.

Read more about Capecitabine

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