Active Ingredient: Melphalan
Melphalan, at conventional intravenous dosage, is indicated in the treatment of advanced ovarian cancer.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
0.2 - 0.2 mg per kg of body weight
From 0.2 To 0.2 mg per kg of body weight once every day for 5 day(s)
A typical regimen is 0.2 mg/kg bodyweight/day orally for 5 days. This is repeated every 4-8 weeks, or as soon as the bone marrow has recovered. Melphalan has also been used intravenously in the treatment of ovarian carcinoma.
Intravenous
0.3 - 1 mg per kg of body weight
From 0.3 To 1 mg per kg of body weight once every 28 day(s)
When used intravenously as a single agent, a dose of 1 mg/kg body weight (approximately 40 mg/m² body surface area) given at intervals of 4 weeks has often been used.
When combined with other cytotoxic drugs, intravenous doses of between 0.3 and 0.4 mg/kg body weight (12 to 16 mg/m² body surface area) have been used at intervals of 4 to 6 weeks.
Intravenous
12 - 40 mg per m² of body surface area (BSA)
From 12 To 40 mg per m² of body surface area (BSA) once every 28 day(s)
When used intravenously as a single agent, a dose of 1 mg/kg body weight (approximately 40 mg/m² body surface area) given at intervals of 4 weeks has often been used.
When combined with other cytotoxic drugs, intravenous doses of between 0.3 and 0.4 mg/kg body weight (12 to 16 mg/m² body surface area) have been used at intervals of 4 to 6 weeks.
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