Malignant pleural effusion

Active Ingredient: Bleomycin

Indication for Bleomycin

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

60,000 IU

Route of admnistration


Defined daily dose

60,000 - 60,000 [iU]

Dosage regimen

From 60,000 To 60,000 [iU] once every 28 day(s)

Detailed description

60 × 103 IU in 100 mL physiological saline solution intrapleurally, as a single dose, which can be repeated after 2-4 weeks, depending on the response. Since approximately 45% of bleomycin is absorbed, this should be taken into account for the lifetime cumulative dose (body surface area, kidney function and lung function).

Dosage considerations

Following drainage of the pleural cavity, bleomycin, dissolved in 100 ml physiological saline solution, is instilled via the puncture cannula or drainage catheter. The cannula or catheter is then removed. In order to ensure uniform distribution of the bleomycin in the serous cavity, the position of the patient should be changed every 5 minutes for a period of 20 minutes. Approximately 45% of Bleomycin will be absorbed; this has to be considered for the total dose (body surface area, kidney function, lung function).

Active ingredient

Bleomycin is a mixture of basic, water-soluble glycopeptide-antibiotics with cytotoxic activity. Bleomycin acts by interacting with both single and double-stranded DNA (deoxyribonucleic acid) leading to both single and double-strand scission, which leads in turn to inhibition of cell division, inhibition of growth and inhibition of DNA synthesis. Bleomycin can also influence RNA (ribonucleic acid) and protein biosynthesis to a lesser extent.

Read more about Bleomycin

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