Active Ingredient: Perindopril
For this indication, competent medicine agencies globally authorize below treatments:
Oral, between 2.5 milligrams perindopril and 5 milligrams perindopril, once daily at morning, over the duration of 1 month. Afterwards, oral, between 2.5 milligrams perindopril and 10 milligrams perindopril, once daily at morning.
The dose should be individualised according to the patient profile and blood pressure response.
Perindopril may be used in monotherapy or in combination with other classes of antihypertensive therapy.
The recommended starting dose is 5 mg given once daily in the morning.
Patients with a strongly activated renin-angiotensin-aldosterone system (in particular, renovascular hypertension, salt and/or volume depletion, cardiac decompensation or severe hypertension) may experience an excessive drop in blood pressure following the initial dose. A starting dose of 2.5 mg is recommended in such patients and the initiation of treatment should take place under medical supervision.
The dose may be increased to 10 mg once daily after one month of treatment.
Symptomatic hypotension may occur following initiation of therapy with perindopril; this is more likely in patients who are being treated concurrently with diuretics. Caution is therefore recommended since these patients may be volume and/or salt depleted.
If possible, the diuretic should be discontinued 2 to 3 days before beginning therapy with perindopril.
In hypertensive patients in whom the diuretic cannot be discontinued, therapy with perindopril should be initiated with a 2.5 mg dose. Renal function and serum potassium should be monitored. The subsequent dosage of perindopril should be adjusted according to blood pressure response. If required, diuretic therapy may be resumed.
In elderly patients treatment should be initiated at a dose of 2.5 mg which may be progressively increased to 5 mg after one month then to 10 mg if necessary depending on renal function.
It is recommended to be taken once daily in the morning before a meal.
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