Perindopril
Also known as: Perindopril arginine
Active ingredient description
Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (Angiotensin Converting Enzyme ACE). The converting enzyme, or kinase, is an exopeptidase that allows conversion of angiotensin I into the vasoconstrictor angiotensin II as well as causing the degradation of the vasodilator bradykinin into an inactive heptapeptide. Inhibition of ACE results in a reduction of angiotensin II in the plasma, which leads to increased plasma renin activity (by inhibition of the negative feedback of renin release) and reduced secretion of aldosterone. Since ACE inactivates bradykinin, inhibition of ACE also results in an increased activity of circulating and local kallikrein-kinin systems (and thus also activation of the prostaglandin system).
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
Medicines
Perindopril is the active ingredient of these drugs:
South Africa
Turkey
Brazil Hong Kong
South Africa
Poland
South Africa
Tunisia
South Africa
South Africa
South Africa
Spain
Austria
Australia Brazil Cyprus Ecuador Finland
Hong Kong
Poland
Romania
Singapore
Australia
Australia
Austria
Turkey
South Africa
South Africa
Ireland
Turkey
Singapore
Hong Kong
Poland
Australia Germany
Lithuania
Estonia Lithuania
Hong Kong
South Africa
Turkey
Estonia Lithuania Poland Romania
Poland
Estonia Lithuania Poland Romania
Australia South Africa
Romania
Italy
Hong Kong Singapore
Turkey
South Africa
South Africa
Turkey
Estonia Lithuania Poland
Tunisia
Romania
South Africa
South Africa
Poland
Perindopril is also found within below combination drugs:
ACEPER PLUS , ACERTALIX , ACERTANLO , ACERTIL PLUS , ACERYCAL , ACTI-PREX PLUS , AMLESSA , AMLESSINI , AMLOPER , ARPLEXAM , BEATIL , BI-THERAPRIL , BIPRETERAX , BOTINERO , CIPLASYL PLUS , CIRCATOR PLUS , CO-AMLESSA , CO-DALNESSA , CO-PERINDALON , CO-PERINEVA , CO-PRENESSA , CO-PRESOMYL , CO-PRESTARIUM , CO-THERAPRIL , COPRENESSA , COSIMPREL , COSYREL , COVERAM , COVERDINE , COVERLAM , COVERON PLUS , COVERSYL COMP , COVERSYL PLUS , DALNESSA , DALNEVA , DANURIT , EUVASCOR , FLAMIPAX , IDAPREX COMBI , INDIX COMBI , INDOSYL COMBI , LIPERCOSYL , LIPERTANCE , LOPRIDAM , MIXANVAL , NOLIPREL , NOLITERAX , NORIPLEX , NORMOTRI , NORPLEXAM , PADERO PLUS , PANOPRIST , PARATERAX , PARVAXOR , PEARINDA PLUS , PENDREX PLUS , PERAM , PERDAPAX , PERDUO , PERIDAY PLUS , PERILEXIN , PERINDAP , PERINDO COMBI , PERIVEL PLUS , PERPRIL PLUS , PREAMLESSA , PREDONIUM , PRELECTAL , PRENEWEL , PRESTALIA , PRESTANCE , PRESTARIUM COMBI , PRESTERAM , PRESTILOL , PRESTOZEK COMBI , PRETERAX , PRETERVAL , PREXAREL , PREXUM COMBI , PREXUM PLUS , PRIAMLO , PRINDAL , RATEN PLUS , REAPTAN , ROSAMERA , ROXAMPEX , ROXIPER , SCALIANT , SERPERIL PLUS , TACERNOL , TAKAWITA , TERAXANS , TERTENSIF KOMBI , TONARSSA , TRIPLIAM , TRIPLIXAM , TRIVERAM , VECTORYL PLUS , VIACORAM , VIACORLIX , VIDONORM , VILPIN COMBI
Structural formula
Chemical formula: C₁₉H₃₂N₂O₅
Molecular mass: 368.468 g/mol