ARPLEXAM

This brand name is authorized in Estonia, Lithuania

Active ingredients

The drug ARPLEXAM contains a combination of these active pharmaceutical ingredients (APIs):

1 Perindopril
UNII TFT5IM1KGB - PERINDOPRIL ARGININE

Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (Angiotensin Converting Enzyme ACE). The converting enzyme, or kinase, is an exopeptidase that allows conversion of angiotensin I into the vasoconstrictor angiotensin II as well as causing the degradation of the vasodilator bradykinin into an inactive heptapeptide. Inhibition of ACE results in a reduction of angiotensin II in the plasma, which leads to increased plasma renin activity (by inhibition of the negative feedback of renin release) and reduced secretion of aldosterone. Since ACE inactivates bradykinin, inhibition of ACE also results in an increased activity of circulating and local kallikrein-kinin systems (and thus also activation of the prostaglandin system).

Read about Perindopril
2 Indapamide
UNII F089I0511L - INDAPAMIDE

Indapamide is a sulfonamide derivative with an indole ring, pharmacologically related to thiazide diuretics, which acts by inhibiting the reabsorption of sodium in the cortical dilution segment. It increases the urinary excretion of sodium and chlorides and, to a lesser extent, the excretion of potassium and magnesium, thereby increasing urine output and having an antihypertensive action.

Read about Indapamide
3 Amlodipine
UNII 864V2Q084H - AMLODIPINE BESYLATE

Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.

Read about Amlodipine

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
C09BX01 C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BX ACE inhibitors, other combinations
Discover more medicines within C09BX01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: EE Ravimiamet Identifier(s): 1587607, 1587618, 1587629, 1587630, 1587641, 1587652, 1587663, 1587674, 1587685, 1587696, 1587708, 1587719, 1587720, 1587731, 1587742, 1587753, 1587764, 1587775, 1587786, 1587797, 1587821, 1587832, 1587843, 1587854, 1587865, 1650923, 1650934, 1650945, 1650956, 1650967, 1762084, 1762095, 1762107, 1762118, 1762129, 1762130, 1762141, 1762152
Country: LT Valstybinฤ— vaistลณ kontrolฤ—s tarnyba Identifier(s): 1066871, 1066872, 1066873, 1066874, 1066875, 1072852, 1072853, 1072854, 1072855, 1072856, 1072857, 1072858, 1072859, 1072860, 1072861, 1072862, 1072863, 1072864, 1072865, 1072866, 1072867, 1072871, 1072872, 1072873, 1072874, 1073710, 1073711, 1073712, 1073713, 1073714, 1084832, 1084833, 1084834, 1084835, 1084836, 1084837, 1084838, 1084839

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