This brand name is authorized in Hong Kong
The drug ACERTIL PLUS contains a combination of these active pharmaceutical ingredients (APIs):
UNII TFT5IM1KGB - PERINDOPRIL ARGININE
Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (Angiotensin Converting Enzyme ACE). The converting enzyme, or kinase, is an exopeptidase that allows conversion of angiotensin I into the vasoconstrictor angiotensin II as well as causing the degradation of the vasodilator bradykinin into an inactive heptapeptide. Inhibition of ACE results in a reduction of angiotensin II in the plasma, which leads to increased plasma renin activity (by inhibition of the negative feedback of renin release) and reduced secretion of aldosterone. Since ACE inactivates bradykinin, inhibition of ACE also results in an increased activity of circulating and local kallikrein-kinin systems (and thus also activation of the prostaglandin system).
UNII F089I0511L - INDAPAMIDE
Indapamide is a sulfonamide derivative with an indole ring, pharmacologically related to thiazide diuretics, which acts by inhibiting the reabsorption of sodium in the cortical dilution segment. It increases the urinary excretion of sodium and chlorides and, to a lesser extent, the excretion of potassium and magnesium, thereby increasing urine output and having an antihypertensive action.
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
|Perindopril and diuretics
|C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BA ACE inhibitors and diuretics
This drug has been assigned below unique identifiers within the countries it is being marketed:
|Department of Health Drug Office
|Identifier(s): 57743, 57744, 65077
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