Active Ingredient: Cefotaxime
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
0.5 - 0.5 g
From 0.5 To 0.5 g once every day for 1 day(s)
For the treatment of gonorrhoea in adults, 500mg administered as a single administration.
For IV, cefotaxime for injection 500 mg is dissolved in at least 2 ml water for injections, cefotaxime for injection 1 g in at least 4 ml and subsequently injected directly into the vein over 3 to 5 minutes or after clamping of the infusion tube into the distal end of the tube. During post-marketing surveillance, potentially life-threatening arrhythmia has been reported in a very few patients who received rapid intravenous administration of cefotaxime through a central venous catheter.
For brief infusion 2 g of cefotaxime for injection is dissolved in 100 ml of isotonic sodium chloride or glucose solution and subsequently IV infused over 50 to 60 minutes. Another compatible infusion solution can also be used for the solution.
Intramuscular
0.5 - 0.5 g
From 0.5 To 0.5 g once every day for 1 day(s)
For the treatment of gonorrhoea in adults, 500 mg administered as a single administration.
Cefotaxime for injection 500 mg is dissolved in 2 ml and cefotaxime for injection 1 g in 4 ml water for injections respectively. Afterwards the injection should take place deep into the gluteal muscle. Pain with the IM injection can be avoided by dissolving cefotaxime for injection 500mg in 2ml or cefotaxime for Injection 1 g in 4 ml 1% lidocaine solution. An intravascular injection is to be avoided in this case, since with intravascular administration lidocaine may lead to unrest, tachycardia, disturbances of cardiac conduction as well as vomiting and cramp. Cefotaxime reconstituted with lidocaine should not be administered to infants under 30 months.
It is recommended that no more than 4 ml be injected unilaterally. If the daily dose exceeds 2 g cefotaxime or if cefotaxime is injected more frequently than twice per day, the IV route is recommended.
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