Active Ingredient: Vigabatrin
Kigabeq is indicated in infants and children from 1 month to less than 7 years of age for treatment in monotherapy of infantile spasms (West’s syndrome).
For this indication, competent medicine agencies globally authorize below treatments:
Oral
25 - 150 mg per kg of body weight
From 12.5 To 75 mg per kg of body weight 2 time(s) per day every day
50 mg per kg of body weight
Monotherapy for infantile spasms (West’s Syndrome) The recommended starting dose is 50 mg/kg/day. Subsequent dosing can be titrated by 25 mg/kg/day increments every 3 days up to the maximum recommended dose of 150 mg/kg/day.
Number of soluble tablets according to body weight, starting dose and dose increment in infantile spasms:
| Body weight (kg) | Starting dose of 50 mg/kg/day | Proposed doses for first titration step (75 mg/kg/day) (Day 3) | Proposed doses for second titration step (100 mg/kg/day) (Day 6) |
|---|---|---|---|
| 3 | 0.5 × 100 mg tablet morning | 1.0 × 100 mg tablet morning | 1.5 × 100 mg tablet morning |
| 1 × 100 mg tablet evening | 1.5 × 100 mg tablet evening | 1.5 × 100 mg tablet evening | |
| 4 | 1 × 100 mg tablet morning | 1.5 × 100 mg tablet morning | 2 × 100 mg tablet morning |
| 1 × 100 mg tablet evening | 1.5 × 100 mg tablet evening | 2 × 100 mg tablet evening | |
| 5 | 1 × 100 mg tablet morning | 1.5 × 100 mg tablet morning | 2.5 × 100 mg tablet morning |
| 1.5 × 100 mg tablet evening | 2 × 100 mg tablet evening | 2.5 × 100 mg tablet evening | |
| 6 | 1.5 × 100 mg tablet morning | 2 × 100 mg tablet morning | 3 × 100 mg tablet morning |
| 1.5 × 100 mg tablet evening | 2.5 × 100 mg tablet evening | 3 × 100 mg tablet evening | |
| 7 | 1.5 × 100 mg tablet morning | 2.5 × 100 mg tablet morning | 3.5 × 100 mg tablet morning |
| 2 × 100 mg tablet evening | 2.5 × 100 mg tablet evening | 3.5 × 100 mg tablet evening | |
| 8 | 2 × 100 mg tablet morning | 3 × 100 mg tablet morning | 4 × 100 mg tablet morning |
| 2 × 100 mg tablet evening | 3 × 100 mg tablet evening | 4 × 100 mg tablet evening | |
| 9 | 2 × 100 mg tablet morning | 3.5 × 100 mg tablet morning | 4.5 × 100 mg tablet morning |
| 2.5 × 100 mg tablet evening | 3.5 × 100 mg tablet evening | 4.5 × 100 mg tablet evening | |
| 10 | 0.5 × 500 mg tablet morning | 0.5 × 500 mg tablet morning | 1 × 500 mg tablet morning |
| 0.5 × 500 mg tablet evening | 1 × 500 mg tablet evening | 1 × 500 mg tablet evening | |
| 11 | 2.5 × 100 mg tablet morning | 4 × 100 mg tablet morning | 1 × 500 mg tablet morning |
| 3 × 100 mg tablet evening | 4 × 100 mg tablet evening | 1 × 500 mg και 1 × 100 mg tablet evening | |
| 12 | 3 × 100 mg tablet morning | 4.5 × 100 mg tablet morning | 1 × 500 mg και 1 × 100 mg tablet morning |
| 3 × 100 mg tablet evening | 4.5 × 100 mg tablet evening | 1 × 500 mg και 1 × 100 mg tablet evening | |
| 13 | 3 × 100 mg tablet morning | 4.5 × 100 mg tablet morning | 1 × 500 mg και 1 × 100 mg tablet morning |
| 3.5 × 100 mg tablet evening | 1 × 500 mg tablet evening | 1 × 500 mg και 2 × 100 mg tablet evening | |
| 14 | 3.5 × 100 mg tablet morning | 1 × 500 mg tablet morning | 1 × 500 mg και 2 × 100 mg tablet morning |
| 3.5 × 100 mg tablet evening | 1 × 500 mg tablet evening | 1 × 500 mg και 2 × 100 mg tablet evening | |
| 15 | 0.5 × 500 mg tablet morning | 1 × 500 mg tablet morning | 1.5 × 500 mg tablet morning |
| 1 × 500 mg tablet evening | 1 × 500 mg και 1 × 100 mg tablet evening | 1.5 × 500 mg tablet evening | |
| 16 | 4 × 100 mg tablet morning | 1 × 500 mg και 1 × 100 mg tablet morning | 1 × 500 mg και 3 × 100 mg tablet morning |
| 4 × 100 mg tablet evening | 1 × 500 mg και 1 × 100 mg tablet evening | 1 × 500 mg και 3 × 100 mg tablet evening |
Vigabatrin is for oral or gastric use and may be taken before or after meals. Gastric administration should be used for children who cannot swallow, but can be fed by enteral route.
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