Depressive illness

Active Ingredient: Clomipramine

Indication for Clomipramine

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

In the management of endogenous depression including manic depression, periodic and involutional depression, reactive and neurotic depression.

For this indication, competent medicine agencies globally authorize below treatments:

25-50 mg once daily and thereafter 75–150 mg once daily

For:

Dosage regimens

Intramuscular, between 25 milligrams clomipramine and 50 milligrams clomipramine, once daily. Afterwards, intramuscular, between 75 milligrams clomipramine and 150 milligrams clomipramine, once daily.

10 mg daily with gradual increments to 30-250 mg daily

For:

Dosage regimens

Oral, in total between 10 milligrams clomipramine and 25 milligrams clomipramine, daily. Afterwards, oral, in total between 30 milligrams clomipramine and 250 milligrams clomipramine, daily. The maximum allowed total dose is 250 milligrams clomipramine daily.

Detailed description

The usual daily dosage is in the range of 30 to 75 mg in single or divided doses. Initial dosage should be 10 mg/day with gradual increments to 30-150 mg/day in divided doses or as a single dose at bedtime. Dosage may exceed the stated range if necessary up to a maximum of 250 mg.

The dosage should be adapted to the individual patient’s condition. The aim is to achieve an optimum effect while keeping the doses as low as possible and increasing them cautiously. After a response has been obtained, maintenance therapy should be continued at the optimum dose to avoid relapse. Patients with a history of recurrent depression require maintenance treatment for a longer duration. Duration of maintenance treatment and need for further treatment should be reviewed periodically.

Abrupt discontinuation of clomipramine therapy should be avoided because of possible withdrawal symptoms. Therefore, dosage should be stopped gradually after regular use for long duration and the patient should be monitored carefully when clomipramine therapy is discontinued.

Dosage considerations

Clomipramine can be administered with or without food.

50-75 mg once daily

For:

Dosage regimens

Intravenous, between 50 milligrams clomipramine and 75 milligrams clomipramine, once daily.

10 mg daily with very slow cautious increments to 30-75 mg daily

For:

Dosage regimens

Oral, in total between 10 milligrams clomipramine and 50 milligrams clomipramine, daily.

Detailed description

Elderly patients generally show a stronger response to clomipramine than patients of intermediate age groups. Clomipramine should be used with caution in elderly patients and doses should be increased cautiously. Daily dose should generally be low, initiated at the lowest level (10 mg) with very slow cautious increments to 30-75 mg daily.

The dosage should be adapted to the individual patient’s condition. The aim is to achieve an optimum effect while keeping the doses as low as possible and increasing them cautiously. After a response has been obtained, maintenance therapy should be continued at the optimum dose to avoid relapse. Patients with a history of recurrent depression require maintenance treatment for a longer duration. Duration of maintenance treatment and need for further treatment should be reviewed periodically.

Abrupt discontinuation of clomipramine therapy should be avoided because of possible withdrawal symptoms. Therefore, dosage should be stopped gradually after regular use for long duration and the patient should be monitored carefully when clomipramine therapy is discontinued.

Dosage considerations

Clomipramine can be administered with or without food.

Active ingredient

Clomipramine

The therapeutic activity of clomipramine is believed to be based on its ability to inhibit the neuronal re-uptake of noradrenaline (NA) and serotonin (5-HT) released in the synaptic cleft, with inhibition of 5-HT reuptake being the more important of these activities.

Read more about Clomipramine

Related medicines

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.