Clomipramine Other names: Chlorimipramine Monochlorimipramine

Chemical formula: C₁₉H₂₃ClN₂  Molecular mass: 314.852 g/mol  PubChem compound: 2801

Active ingredient description

The therapeutic activity of clomipramine is believed to be based on its ability to inhibit the neuronal re-uptake of noradrenaline (NA) and serotonin (5-HT) released in the synaptic cleft, with inhibition of 5-HT reuptake being the more important of these activities.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N06AA04 Clomipramine N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AA Non-selective monoamine reuptake inhibitors
Discover more medicines within N06AA04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ANAFRANIL Prolonged-release, film-coated tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 17321-77-6
CAS Substance: 303-49-1
DrugBank Drug: DB01242
KEGG Drug: D00811
PubChem Compound: 2801
RxNorm Ingredient: 2597
SNOMED-CT Concept: 349855006
Clomipramine (substance)
SNOMED-CT Concept: 372903001
Clomipramine (substance)
UNII Identifier: NUV44L116D


Clomipramine is an active ingredient of these brands:

United States (US)

Australia (AU)


Austria (AT)

Brazil (BR)

Canada (CA)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Nigeria (NG)


Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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