Nocturnal enuresis

Active Ingredient: Amitriptyline

Indication for Amitriptyline

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

For this indication, competent medicine agencies globally authorize below treatments:

10-50 mg daily

Route of admnistration

Oral

Defined daily dose

10 - 50 mg

Dosage regimen

From 10 To 50 mg once every day for 90 day(s)

Detailed description

The recommended doses for:

  • children aged 6 to 10 years: 10 mg–20 mg. A suitable dosage form should be used for this age group.
  • children aged 11 years and above: 25 mg–50 mg daily

The dose should be increased gradually. Dose to be administered 1-1½ hours before bedtime. An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome.

The maximum period of treatment course should not exceed 3 months. If repeated courses of amitriptyline are needed, a medical review should be conducted every 3 months. When stopping treatment, amitriptyline should be withdrawn gradually.

Dosage considerations

Dose to be administered 1-1½ hours before bedtime.

Active ingredient

Amitriptyline

Amitriptyline is a tricyclic antidepressant and an analgesic. It prevents the re-uptake, and hence the inactivation of noradrenaline and serotonin at nerve terminals. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity.

Read more about Amitriptyline

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