Active Ingredient: Levodopa
Levodopa is indicated for the intermittent treatment of episodic motor fluctuations (OFF episodes) in adult patients with Parkinson's disease (PD) treated with a levodopa/dopa-decarboxylase inhibitor.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Respiratory (Inhalation), 66 milligrams levodopa, 1 to 5 times daily. The maximum allowed total dose is 330 milligrams levodopa daily.
Patients should be on a stable levodopa/dopa-decarboxylase inhibitor (e.g. carbidopa or benserazide) regimen before starting inhaled levodopa.
Patients selected for treatment with inhaled levodopa should be able to recognize the onset of their 'OFF' symptoms and be capable of preparing the inhaler or else have a responsible care giver able to prepare the inhaler for them when required.
Levodopa should be inhaled when symptoms, motor or non-motor, of an OFF period start to return.
The recommended dose 66 mg up to 5 times per day. The maximum daily dose should not exceed 330 mg. It is not recommended to take more than 66 mg per OFF period. Exceeding the recommended dose may lead to increased levodopa associated adverse reactions.
Abrupt dose reduction or withdrawal of any levodopa medicinal product should be carefully observed, particularly in patients who are also receiving neuroleptics.
No dose adjustment of inhaled levodopa is required for elderly patients (≥65 years). There is only limited data available in very elderly patients (≥75 years).
The maximum time between inhalation of the powder from the first and second dose should not exceed 10 minutes.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.