Active Ingredient: Lisinopril
Short-term (6 weeks) treatment of haemodynamically stable patients within 24 hours of an acute myocardial infarction.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 5 milligrams lisinopril, once daily, over the duration of 2 days. Afterwards, oral, 10 milligrams lisinopril, once daily, over the duration of 6 weeks.
Patients should receive, as appropriate, the standard recommended treatments such as thrombolytics, aspirin, and betablockers. Intravenous or transdermal glyceryl trinitrate may be used together with lisinopril.
Treatment with lisinopril may be started within 24 hours of the onset of symptoms. Treatment should not be started if systolic blood pressure is lower than 100 mmHg. The first dose of lisinopril is 5 mg given orally, followed by 5 mg after 24 hours, 10 mg after 48 hours and then 10 mg once daily. Patients with a low systolic blood pressure (120 mmHg or less) when treatment is started or during the first 3 days after the infarction should be given a lower dose – 2.5 mg orally.
In cases of renal impairment (creatinine clearance <80 ml/min), the initial lisinopril dosage should be adjusted according to the patient’s creatinine clearance.
The maintenance dose is 10 mg once daily. If hypotension occurs (systolic blood pressure less than or equal to 100 mmHg) a daily maintenance dose of 5 mg may be given with temporary reductions to 2.5 mg if needed. If prolonged hypotension occurs (systolic blood pressure less than 90 mm Hg for more than 1 hour) lisinopril should be withdrawn.
Treatment should continue for 6 weeks and then the patient should be re-evaluated. Patients who develop symptoms of heart failure should continue with lisinopril.
Lisinopril should be taken at approximately the same time each day. The absorption of lisinopril is not affected by food.
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