Moderate to high-risk Transient Ischemic Attack (TIA) or minor Ischemic Stroke (IS)

Active Ingredient: Clopidogrel

Indication for Clopidogrel

Population group: only adults (18 years old or older)

Therapeutic intent: Preventive action

Clopidogrel in combination with ASA is indicated in adult patients with moderate to high-risk TIA (ABCD2¹ score ≥4) or minor IS (NIHSS² ≤3) within 24 hours of either the TIA or IS event.

For this indication, competent medicine agencies globally authorize below treatments:

300 mg as loading dose and thereafter 75 mg once daily for 21 days

For:

Dosage regimens

Oral, 300 milligrams clopidogrel, 1 one dose, over the duration of 1 day. Afterwards, oral, 75 milligrams clopidogrel, once daily, over the duration of 21 days.

Detailed description

Adult patients with moderate to high-risk TIA (ABCD2 score ≥4) or minor IS (NIHSS ≤3) should be given a loading dose of clopidogrel 300 mg followed by clopidogrel 75 mg once daily and ASA (75 mg-100 mg once daily). Treatment with clopidogrel and ASA should be started within 24 hours of the event and be continued for 21 days followed by single antiplatelet therapy.

If a dose is missed:

Within less than 12 hours after regular scheduled time: patients should take the dose immediately and then take the next dose at the regular scheduled time.
For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.

Active ingredient

Clopidogrel
Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. Read more about Clopidogrel

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