Squamous cell carcinoma (SCC) of the head and neck, cervix, external genitalia

Indication for Bleomycin

Population group: Suitable for both men and women, only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

10,000-15,000 IU/m² once or twice a week every 3-4 weeks

Route of admnistration

Intramuscular

Defined daily dose

10,000 - 15,000 [iU] per m² of body surface area (BSA)

Dosage regimen

From 10,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)

Detailed description

Intramuscular or intravenous injection of 10-15 × 103 IU/m² body surface area (BSA), once or twice a week, at intervals of 3-4 weeks up to a lifetime cumulative dose of 360 × 103 IU.

Dosage considerations

Dissolve the contents of a vial in 1-5 mL physiological saline solution. Since repeated i.m. injections at the same site can cause local discomfort, it is recommended to change the injection site regularly. In the event of excessive local discomfort, a local anaesthetic can be added to the injection solution, e.g. 1.5-2 mL lidocaine HCl 1%.

10,000-15,000 IU/m² once or twice a week every 3-4 weeks

Route of admnistration

Intravenous

Defined daily dose

10,000 - 15,000 [iU] per m² of body surface area (BSA)

Dosage regimen

From 10,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)

Detailed description

Intramuscular or intravenous injection of 10-15 × 103 IU/m² body surface area (BSA), once or twice a week, at intervals of 3-4 weeks up to a lifetime cumulative dose of 360 × 103 IU.

Dosage considerations

Intravenous injection

Dissolve the contents of a vial in 5-10 mL physiological saline solution and inject slowly over a period of 5-10 minutes. Fast bolus injections are to be avoided, because they lead to high intrapulmonary plasma concentrations, increasing the risk of lung damage.

Intravenous infusion

Dissolve the contents of a vial in 200-1,000 mL physiological saline solution.

Active ingredient

Bleomycin is a mixture of basic, water-soluble glycopeptide-antibiotics with cytotoxic activity. Bleomycin acts by interacting with both single and double-stranded DNA (deoxyribonucleic acid) leading to both single and double-strand scission, which leads in turn to inhibition of cell division, inhibition of growth and inhibition of DNA synthesis. Bleomycin can also influence RNA (ribonucleic acid) and protein biosynthesis to a lesser extent.

Read more about Bleomycin

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