Symptomatic heart failure

Active Ingredient: Ramipril

Indication for Ramipril

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

1.25 mg once daily followed by doubling the dose every 1-2 weeks up to 10 mg daily


Dosage regimens

Oral, between 1.25 milligrams ramipril and 10 milligrams ramipril, once daily. The maximum allowed total dose is 10 milligrams ramipril daily.

Detailed description

Starting dose:

In patients stabilized on diuretic therapy, the recommended initial dose is 1.25 mg daily.

Titration and maintenance dose:

Ramipril should be titrated by doubling the dose every one to two weeks up to a maximum daily dose of 10 mg. Two administrations per day are preferable.

Dosage considerations

It is recommended that ramipril is taken each day at the same time of the day.

Ramipril can be taken before, with or after meals, because food intake does not modify its bioavailability.

Active ingredient


Ramiprilat, the active metabolite of the prodrug ramipril, inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II). In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin. Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation.

Read more about Ramipril

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