Major depressive episodes

Active Ingredient: Sertraline

Indication for Sertraline

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

50 mg once daily for a week and thereafter 50-200 mg once daily

For:

Dosage regimens

Oral, 50 milligrams sertraline, once daily, over the duration of 1 week. Afterwards, oral, between 50 milligrams sertraline and 200 milligrams sertraline, once daily.

Detailed description

Initial treatment

Sertraline treatment should be started at a dose of 50 mg/day.

Titration

Patients not responding to a 50 mg dose may benefit from dose increases. Dose changes should be made in steps of 50 mg at intervals of at least one week, up to a maximum of 200 mg/day. Changes in dose should not be made more frequently than once per week given the 24-hour elimination half life of sertraline.

The onset of therapeutic effect may be seen within 7 days. However, longer periods are usually necessary to demonstrate therapeutic response, especially in OCD.

Maintenance

Dosage during long-term therapy should be kept at the lowest effective level, with subsequent adjustment depending on therapeutic response.

Dosage considerations

Sertraline should be administered once daily, either in the morning or evening.

Sertraline can be administered with or without food.

Active ingredient

Sertraline

Sertraline is a potent and specific inhibitor of neuronal serotonin (5-HT) uptake in vitro, which results in the potentiation of the effects of 5-HT in animals. It has only very weak effects on norepinephrine and dopamine neuronal reuptake.

Read more about Sertraline

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