Chronic anal fissure

Active Ingredient: Glyceryl trinitrate

Indication for Glyceryl trinitrate

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

3 mg in 2 divided doses daily

Route of admnistration

Rectal

Defined daily dose

3 mg

Dosage regimen

1.5 mg 2 time(s) per day every day

Detailed description

A finger covering, such as cling film or a finger cot, may be placed on the finger to be used to apply the ointment. (Finger cots to be obtained separately from local pharmacy or surgical supplies retailer or cling film from local store). The finger is placed along side a 2.5cm dosing line which is provided on the outside carton in which glyceryl trinitrate is supplied, and a strip of ointment the length of the line is expressed onto the end of the finger by gently squeezing the tube. The amount of ointment expressed is approximately 375 mg (1.5 mg GTN). The covered finger is then gently inserted into the anal canal to the distal interphalangeal joint of the finger and applied circumferentially to the anal canal.

The dose delivered from the 4 mg/g ointment is 1.5 mg glyceryl trinitrate. The dose is to be applied intra-anally every twelve hours. Treatment may be continued until the pain abates, up to a maximum of 8 weeks.

Glyceryl trinitrate should be used following conservative treatment failure for acute symptoms of anal fissure.

Active ingredient

Glyceryl trinitrate

Glyceryl trinitrate is a vasodilator and is used for angina of effort. Vasodilation is achieved by the releasing of free redical nitric oxide which activates guanylate cyclase and increases synthesis of guanosine 3′ and 5′-monophosphate with resultant effects on the phosphorylation of proteins in smooth muscle. If taken in excess, its vasodilatory effect can cause headache.

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