Prevention of nausea and vomiting associated with chemotherapy

Active Ingredient: Palonosetron

Indication for Palonosetron

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Therapeutic intent: Preventive action

Palonosetron is indicated in paediatric patients 1 month of age and older for the prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy and prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments:

20 μg/kg

Route of admnistration

Intravenous

Defined daily dose

20 - 20 ug per kg of body weight

Dosage regimen

From 20 To 20 ug per kg of body weight once every day

Detailed description

20 micrograms/kg (the maximum total dose should not exceed 1500 micrograms) palonosetron administered as a single 15 minute intravenous infusion beginning approximately 30 minutes before the start of chemotherapy.

The safety and efficacy of palonosetron in children aged less than 1 month have not been established. No data are available. There are limited data on the use of palonosetron in the prevention of nausea and vomiting in children under 2 years of age.

Dosage considerations

Palonosetron should be administered as a single 15 minute intravenous infusion.

Active ingredient

Palonosetron

Palonosetron is a selective high-affinity receptor antagonist of the 5HT3 receptor.

Read more about Palonosetron

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