Severe systemic and/or deep mycoses

Active Ingredient: Amphotericin B

Indication for Amphotericin B

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Amphotericin B is indicated in adults and children aged 1 month to 18 years old for the treatment of severe systemic and/or deep mycoses.

For this indication, competent medicine agencies globally authorize below treatments:

1-3 mg/kg once daily

Route of admnistration


Defined daily dose

1 - 3 mg per kg of body weight

Dosage regimen

From 1 To 3 mg per kg of body weight once every day

Detailed description

Therapy is usually instituted at a daily dose of 1.0 mg/kg of body weight, and increased stepwise to 3.0 mg/kg, as required. Data are presently insufficient to define total dosage requirements and duration of treatment necessary for resolution of mycoses.

Dosage considerations

Amphotericin B should be administered by intravenous infusion over a 30-60 minute period. For doses greater than 5mg/kg/day, intravenous infusion over a 2 hour period is recommended.

Active ingredient

Amphotericin B

Amphotericin B is a macrocyclic, polyene antifungal antibiotic produced by Streptomyces nodosus. The molecule is thought to act by binding to sterols in the fungal cell membrane, with a resulting change in membrane permeability, allowing leakage of a variety of small molecules.

Read more about Amphotericin B

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