Diarrhoea

Active Ingredient: Codeine

Indication for Codeine

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Codeine is indicated for the relief of symptoms of diarrhoea (except diarrhoea caused by poisoning).

For this indication, competent medicine agencies globally authorize below treatments:

15-60 mg every 4-6 hours

For:

Dosage regimens

Oral, between 15 milligrams codeine and 60 milligrams codeine, once every 4 to 6 hours.

Detailed description

Codeine phosphate may be given orally in doses of 15 mg – 60 mg every 4 – 6 hours as needed. If these doses fail to relieve pain, larger doses rarely succeed and may give rise to restlessness and excitement.

The maximum daily dose in adults should not exceed 300 mg.

0.5 mg/kg of body weight every 4-6 hours up to 3 days

For:

Dosage regimens

Oral, 0.5 milligrams codeine per kilogram of body weight, once every 4 to 6 hours.

Detailed description

The usual paediatric dose is 0.5 mg per kg of body weight, every 4 to 6 hours as needed. The total dose should not exceed 240 mg in 24 hours. The duration of treatment should not normally exceed 3 days.

Active ingredient

Codeine

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through μ opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain. The anti-tussive activity of codeine is probably due to its depressant effect on the medullary cough centre in the brain.

Read more about Codeine

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