Codeine

Chemical formula: C₁₈H₂₁NO₃  Molecular mass: 299.364 g/mol  PubChem compound: 5284371

Active ingredient description

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through μ opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain. The anti-tussive activity of codeine is probably due to its depressant effect on the medullary cough centre in the brain.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R05DA04 Codeine R Respiratory system → R05 Cough and cold preparations → R05D Cough suppressants, excl. combinations with expectorants → R05DA Opium alkaloids and derivatives
Discover more medicines within R05DA04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CARE CODEINE Oral liquid Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CODEINE PHOSPHATE Tablet Medicines and Medical Devices Safety Authority (NZ) MPI, EU: SmPC
CODANT Tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 41444-62-6
CAS Substance: 52-28-8
DrugBank Drug: DB00318
KEGG Drug: D03580
PubChem Compound: 5284371
RxNorm Ingredient: 2670
SNOMED-CT Concept: 387494007
Codeine (substance)
UNII Identifier: GSL05Y1MN6
CODEINE PHOSPHATE
UNII Identifier: Q830PW7520
CODEINE

Medicines

Codeine is an active ingredient of these brands:

United States (US)

Australia (AU)

Brazil (BR)

  • (combination) AGUD as CODEINE PHOSPHATE
  • (combination) ALGICOD as CODEINE PHOSPHATE
  • (combination) CODATEN as CODEINE PHOSPHATE
  • (combination) CODEX as CODEINE PHOSPHATE
  • (combination) IMMENSAE as CODEINE PHOSPHATE
  • (combination) PACO as CODEINE PHOSPHATE
  • (combination) TYLEX as CODEINE PHOSPHATE
  • (combination) VICODIL as CODEINE PHOSPHATE

Canada (CA)

Croatia (HR)

  • (combination) CAFFETIN as CODEINE PHOSPHATE SESQUIHYDRATE
  • (combination) PLIVADON as CODEINE PHOSPHATE

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

  • (combination) ALGOCALM as CODEINE PHOSPHATE
  • (combination) BRUFEN PLUS as CODEINE PHOSPHATE
  • (combination) CO-CODAMOL as CODEINE PHOSPHATE
  • (combination) RECIPECT as CODEINE PHOSPHATE
  • (combination) SOLPADEINE as Codeine phosphate hemihydrate

Finland (FI)

  • (combination) ALTERMOL as CODEINE PHOSPHATE
  • (combination) ARDINEX as CODEINE PHOSPHATE
  • (combination) PANACOD as CODEINE PHOSPHATE
  • (combination) PARAMAX-COD as CODEINE PHOSPHATE
  • (combination) RECIPECT as CODEINE PHOSPHATE

France (FR)

Germany (DE)

Hong Kong (HK)

  • (combination) ACTCOFED as CODEINE PHOSPHATE
  • (combination) ACTIFED COMPOUND as CODEINE PHOSPHATE
  • (combination) AENDY as CODEINE PHOSPHATE
  • (combination) ALSEDYL as CODEINE PHOSPHATE
  • (combination) ANMEN as CODEINE PHOSPHATE
  • (combination) ANTICOL COUGH as CODEINE PHOSPHATE
  • (combination) ANTITUSS as CODEINE PHOSPHATE
  • (combination) ARACO as CODEINE PHOSPHATE
  • (combination) ARISTTO as CODEINE PHOSPHATE
  • (combination) ARSECOYL as CODEINE PHOSPHATE
  • (combination) BAILIE as CODEINE PHOSPHATE
  • (combination) BESCOFED as CODEINE PHOSPHATE
  • (combination) BIO-SED as CODEINE PHOSPHATE
  • (combination) BOLSEDYL as CODEINE PHOSPHATE
  • (combination) BROMCOLIN as CODEINE PHOSPHATE
  • (combination) BROMDINE as CODEINE PHOSPHATE
  • (combination) BROMESED as CODEINE PHOSPHATE
  • (combination) BROMETUSIN as CODEINE PHOSPHATE
  • (combination) BRONCODIN as CODEINE PHOSPHATE
  • (combination) BRONCOLIN as CODEINE PHOSPHATE
  • (combination) BRONKIN as CODEINE PHOSPHATE
  • (combination) BROSEDYL as CODEINE PHOSPHATE
  • (combination) CECOBOL as CODEINE PHOSPHATE
  • (combination) CECOL as CODEINE PHOSPHATE
  • (combination) CO-SEDYL as CODEINE PHOSPHATE
  • (combination) CO-TUSIN as CODEINE PHOSPHATE
  • (combination) CO-TUSIU as CODEINE PHOSPHATE
  • (combination) COBELIN as CODEINE PHOSPHATE
  • (combination) COBO as CODEINE PHOSPHATE
  • (combination) COCLEAN as CODEINE PHOSPHATE
  • (combination) COCURE as CODEINE PHOSPHATE
  • (combination) CODEY as CODEINE PHOSPHATE
  • (combination) CODIXINE as CODEINE PHOSPHATE
  • (combination) CODOLAX as CODEINE PHOSPHATE
  • (combination) CODOLAX COMPLEX as CODEINE PHOSPHATE
  • (combination) CODOPLEX as CODEINE PHOSPHATE
  • (combination) COFEDPO as CODEINE PHOSPHATE
  • (combination) COFETOL as CODEINE PHOSPHATE
  • (combination) COFFTIER as CODEINE PHOSPHATE
  • (combination) COFLUKON as CODEINE PHOSPHATE
  • (combination) COL-LERGIC as CODEINE PHOSPHATE
  • (combination) COLASED as CODEINE PHOSPHATE
  • (combination) COLESS COUGH as CODEINE PHOSPHATE
  • (combination) COLSEDYL as CODEINE PHOSPHATE
  • (combination) COMEPHEN as CODEINE PHOSPHATE
  • (combination) COMETIN as CODEINE PHOSPHATE
  • (combination) CONDOSA as CODEINE PHOSPHATE
  • (combination) COPALIN as CODEINE PHOSPHATE
  • (combination) COPAMINE as CODEINE PHOSPHATE
  • (combination) COPHENSIN as CODEINE PHOSPHATE
  • (combination) CORIN as CODEINE PHOSPHATE
  • (combination) CORME as CODEINE PHOSPHATE
  • (combination) CORY as CODEINE PHOSPHATE
  • (combination) COSEDIN as CODEINE PHOSPHATE
  • (combination) COSEDYL as CODEINE PHOSPHATE
  • (combination) COSO as CODEINE PHOSPHATE
  • (combination) COSOTAL as CODEINE PHOSPHATE
  • (combination) COTALIN as CODEINE PHOSPHATE
  • (combination) COTIN as CODEINE PHOSPHATE
  • (combination) CROSEDYL as CODEINE PHOSPHATE
  • (combination) CUPATUSSIN as CODEINE PHOSPHATE
  • (combination) DECOFFA as CODEINE PHOSPHATE
  • (combination) DECOL as CODEINE PHOSPHATE
  • (combination) DEWEAR COUGH as CODEINE PHOSPHATE
  • (combination) DEXCOFED as CODEINE PHOSPHATE
  • (combination) DIMECO as CODEINE PHOSPHATE
  • (combination) DIPHECO as CODEINE PHOSPHATE
  • (combination) DIPHETAN as CODEINE PHOSPHATE
  • (combination) ECOMET as CODEINE PHOSPHATE
  • (combination) ECOSIN as CODEINE PHOSPHATE
  • (combination) EDENA as CODEINE PHOSPHATE
  • (combination) EENDEL LIGHT as CODEINE PHOSPHATE
  • (combination) EFENDEL as CODEINE PHOSPHATE
  • (combination) EIONE COUGH as CODEINE PHOSPHATE
  • (combination) EPHCOUGH as CODEINE PHOSPHATE
  • (combination) EPHECO as CODEINE PHOSPHATE
  • (combination) EPHENDYLN as CODEINE PHOSPHATE
  • (combination) EUROSEDYL as CODEINE PHOSPHATE
  • (combination) FAMISEDYL as CODEINE PHOSPHATE
  • (combination) FEDAC COMPOUND as CODEINE PHOSPHATE
  • (combination) FENCO COUGH as CODEINE PHOSPHATE
  • (combination) FENCODYL as CODEINE PHOSPHATE
  • (combination) FENCOLIN COUGH as CODEINE PHOSPHATE
  • (combination) FENDIL as CODEINE PHOSPHATE
  • (combination) FENDYL as CODEINE PHOSPHATE
  • (combination) FERRALI as CODEINE PHOSPHATE
  • (combination) FESCOFED as CODEINE PHOSPHATE
  • (combination) FOLSEDYL as CODEINE PHOSPHATE
  • (combination) FRICOLIN as CODEINE PHOSPHATE
  • (combination) FUSTALIM as CODEINE PHOSPHATE
  • (combination) GECOL as CODEINE PHOSPHATE
  • (combination) GOBY COUGH as CODEINE PHOSPHATE
  • (combination) GROSEDYL as CODEINE PHOSPHATE
  • (combination) HOLSEDYL as CODEINE PHOSPHATE
  • (combination) JENDEL as CODEINE PHOSPHATE
  • (combination) JENDYL as CODEINE PHOSPHATE
  • (combination) KENDEL as CODEINE PHOSPHATE
  • (combination) KOLSEDYL as CODEINE PHOSPHATE
  • (combination) KONTUSSIN as CODEINE PHOSPHATE
  • (combination) KROSEDYL as CODEINE PHOSPHATE
  • (combination) LAMBAR as CODEINE PHOSPHATE
  • (combination) LAVENDA as CODEINE PHOSPHATE
  • (combination) LECOL as CODEINE PHOSPHATE
  • (combination) LOLSEDYL as CODEINE PHOSPHATE
  • (combination) MECODIN as CODEINE PHOSPHATE
  • (combination) MEGATUSSIC as CODEINE PHOSPHATE
  • (combination) MEPHENDYL as CODEINE PHOSPHATE
  • (combination) MERSIDYL as CODEINE PHOSPHATE
  • (combination) MESADIN as CODEINE PHOSPHATE
  • (combination) METASIN as CODEINE PHOSPHATE
  • (combination) METHARINE as CODEINE PHOSPHATE
  • (combination) MONIC COUGH as CODEINE PHOSPHATE
  • (combination) MROSEDYL as CODEINE PHOSPHATE
  • (combination) MYCODIN as CODEINE PHOSPHATE
  • (combination) NASEDYL as CODEINE PHOSPHATE
  • (combination) NAVOSE as CODEINE PHOSPHATE
  • (combination) NEODINE as CODEINE PHOSPHATE
  • (combination) NOLSEDYL as CODEINE PHOSPHATE
  • (combination) NORVICOL as CODEINE PHOSPHATE
  • (combination) OROSEDYL as CODEINE PHOSPHATE
  • (combination) PAFFEICO as CODEINE PHOSPHATE
  • (combination) PANADEINE as CODEINE PHOSPHATE
  • (combination) PANADOL ULTRA as CODEINE PHOSPHATE
  • (combination) PARCOTEN as CODEINE PHOSPHATE
  • (combination) PECOLIN as CODEINE PHOSPHATE
  • (combination) PHECOBO as CODEINE PHOSPHATE
  • (combination) PHECOMIN-N as CODEINE PHOSPHATE
  • (combination) PHENAZOL as CODEINE PHOSPHATE
  • (combination) PHENCOUGH as CODEINE PHOSPHATE
  • (combination) PHENSEDYN as CODEINE PHOSPHATE
  • (combination) PHENTAGON as CODEINE PHOSPHATE
  • (combination) PHENZINCO as CODEINE PHOSPHATE
  • (combination) POCODYL as CODEINE PHOSPHATE
  • (combination) POLESEDYL as CODEINE PHOSPHATE
  • (combination) POSODIN as CODEINE PHOSPHATE
  • (combination) PRESEDYL as CODEINE PHOSPHATE
  • (combination) PRO-COTIN as CODEINE PHOSPHATE
  • (combination) PRO-PHECO as CODEINE PHOSPHATE
  • (combination) PROCODINE as CODEINE PHOSPHATE
  • (combination) PROCOSED as CODEINE PHOSPHATE
  • (combination) PROCOTUSS as CODEINE PHOSPHATE
  • (combination) PROPHENIN ELIXIR as CODEINE PHOSPHATE
  • (combination) PROSEDIN as CODEINE PHOSPHATE
  • (combination) PROSEDINE as CODEINE PHOSPHATE
  • (combination) PROSEDYL as CODEINE PHOSPHATE
  • (combination) PROSODIN as CODEINE PHOSPHATE
  • (combination) QUENCOL as CODEINE PHOSPHATE
  • (combination) RROSEDYL as CODEINE PHOSPHATE
  • (combination) SECOLIN-F as CODEINE PHOSPHATE
  • (combination) SEDYLIN as CODEINE PHOSPHATE
  • (combination) SENDY as CODEINE PHOSPHATE
  • (combination) SOLSEDYL COUGH as CODEINE PHOSPHATE
  • (combination) SUPHENIN as CODEINE PHOSPHATE
  • (combination) SURSEDYL as CODEINE PHOSPHATE
  • (combination) SURTUSSIN as CODEINE PHOSPHATE
  • (combination) TOLSEDYL as CODEINE PHOSPHATE
  • (combination) TOUSEDYL as CODEINE PHOSPHATE
  • (combination) TRICOS COUGH as CODEINE PHOSPHATE
  • (combination) TROSEDYL as CODEINE PHOSPHATE
  • (combination) TUCOSOL as CODEINE PHOSPHATE
  • (combination) TUCOUSOL as CODEINE PHOSPHATE
  • (combination) TUSINCO as CODEINE PHOSPHATE
  • (combination) TUSSORAL as CODEINE PHOSPHATE
  • (combination) U-CODOBEX as CODEINE PHOSPHATE
  • (combination) U-PHENCO as CODEINE PHOSPHATE
  • (combination) UNI-CODPLEX as CODEINE PHOSPHATE
  • (combination) UNI-COLIN as CODEINE PHOSPHATE
  • (combination) UNI-FEDRA COMPOUND as CODEINE PHOSPHATE
  • (combination) VANDAFU as CODEINE PHOSPHATE
  • (combination) VICKOLAX as CODEINE PHOSPHATE
  • (combination) VOLSEDYL COUGH as CODEINE PHOSPHATE
  • (combination) WINSEDYL as CODEINE PHOSPHATE
  • (combination) XOLSEDYL as CODEINE PHOSPHATE
  • (combination) ZECOL COUGH as CODEINE PHOSPHATE
  • (combination) ZOLLAR as CODEINE PHOSPHATE

Ireland (IE)

  • CODANT as Codeine phosphate hemihydrate

  • (combination) CO-TIPOL as Codeine phosphate hemihydrate
  • (combination) CODIPAR as CODEINE PHOSPHATE
  • (combination) KAPAKE as CODEINE PHOSPHATE
  • (combination) MAXILIEF as odeine phosphate hemihydrate
  • (combination) MIGRALEVE as CODEINE PHOSPHATE
  • (combination) MIGRALEVE PINK as Codeinephosphate
  • (combination) MIGRALEVE YELLOW as Codeine phosphate
  • (combination) NUROFEN PLUS as CODEINE PHOSPHATE
  • (combination) PANADEINE as CODEINE PHOSPHATE
  • (combination) SOLPADEINE as Codeine phosphate hemihydrate
  • (combination) SOLPADOL as CODEINE PHOSPHATE
  • (combination) TYLEX as CODEINE PHOSPHATE
  • (combination) VEGANIN as CODEINE PHOSPHATE

Israel (IL)

Italy (IT)

  • (combination) CODAMOL as CODEINE SULFATE
  • (combination) COEFFERALGAN as CODEINE SULFATE
  • (combination) TACHIDOL as CODEINE SULFATE
  • (combination) ZEUSEFF as CODEINE SULFATE

Lithuania (LT)

  • (combination) SOLPADEINE as Codeine phosphate hemihydrate
  • (combination) ULTRACOD as CODEINE PHOSPHATE

Malta (MT)

Mexico (MX)

  • (combination) TYLEX as CODEINE PHOSPHATE

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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