Codeine

Chemical formula: C₁₈H₂₁NO₃  Molecular mass: 299.364 g/mol  PubChem compound: 5284371

Therapeutic indications

Codeine is indicated for:

Mild to moderate pain

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Codeine is indicated in patients older than 12 years of age for the treatment of acute moderate pain which is not considered to be relieved by other analgesics such as paracetamol or ibuprofen alone.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Diarrhoea

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Codeine is indicated for the relief of symptoms of diarrhoea (except diarrhoea caused by poisoning).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Non-productive cough

Population group: only adults (18 years old or older)

As an anti-tussive for non-productive cough.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Codeine is contraindicated in the following cases:

Acute respiratory depression

Decreased respiratory function

Obstructive airways disease

Chronic obstructive lung disease

Asthma attack

Exacerbation of asthma

Hepatic failure

Hepatic insufficiency

Head injuries or conditions where intracranial pressure is raised

Raised intracranial pressure

Acute alcoholism

Alcohol intoxication

Patients at risk of paralytic ileus

Paralytic ileus

Lactation

Lactation

CYP2D6 ultra-rapid metabolisers

Cytochrome P450 family 2 subfamily D member 6 ultra-rapid metabolizer

Tonsillectomy and/or adenoidectomy for obstructive sleep apnoea syndrome

Population group: only minors (0 - 18 years old)

Obstructive sleep apnea syndrome and additionally at least one of
Tonsillectomy
Adenoid excision

Cough

Population group: only minors (0 - 18 years old)

Cough

Monoamine oxidase inhibitors

Monoamine oxidase inhibitors (MAOIs)

Diarrhoea associated with pseudomembranous colitis or caused by poisoning

at least one of
Clostridium difficile colitis
Diarrhea and additionally Poisoning

Following biliary surgery

Operation on biliary tract

Heart failure secondary to chronic lung disease

Heart failure

Respiratory compromise

Population group: only adolescents (12 years - 18 years old)

Decreased respiratory function

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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