CODOXOL

This brand name is authorized in South Africa

Active ingredients

The drug CODOXOL contains a combination of these active pharmaceutical ingredients (APIs):

1 Codeine
UNII GSL05Y1MN6 - CODEINE PHOSPHATE

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through μ opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain. The anti-tussive activity of codeine is probably due to its depressant effect on the medullary cough centre in the brain.

Read about Codeine
2 Paracetamol
UNII 362O9ITL9D - ACETAMINOPHEN

Paracetamol is a medication used to treat pain and fever. It does appear to selectively inhibit COX activities in the brain, which may contribute to its ability to treat fever and pain.

Read about Paracetamol
3 Caffeine
UNII 3G6A5W338E - CAFFEINE

Caffeine is structurally related to the methylxanthines theophylline and theobromine. Caffeine’s main action is as a CNS stimulant.

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4 Doxylamine
UNII V9BI9B5YI2 - DOXYLAMINE SUCCINATE

Doxylamine, an ethanolamine, first-generation antihistamine crosses the blood-brain barrier and exerts an antiemetic action by selectively binding to H1 receptors in the brain. Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is also a potent anticholinergic.

Read about Doxylamine

Medication package inserts

Below package inserts are available for further reading:

Title Information Source Document Type  
CODOXOL Tablet Health Products Regulatory Authority (ZA) MPI, Generic

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
N02BE51 Paracetamol, combinations excl. psycholeptics N Nervous system → N02 Analgesics → N02B Other analgesics and antipyretics → N02BE Anilides
Discover more medicines within N02BE51

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: ZA Health Products Regulatory Authority Identifier(s): 34/2.8/0489

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