PHARMAGESIC

This brand name is authorized in South Africa

Active ingredients

The drug PHARMAGESIC contains a combination of these active pharmaceutical ingredients (APIs):

1 Codeine
UNII GSL05Y1MN6 - CODEINE PHOSPHATE

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through μ opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain. The anti-tussive activity of codeine is probably due to its depressant effect on the medullary cough centre in the brain.

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2 Meprobamate
UNII 9I7LNY769Q - MEPROBAMATE

Meprobamate is a carbamate with hypnotic, sedative and some muscle relaxant properties. It is used for the short-term treatment of anxiety states, muscle tension and associated conditions where anxiety is present. In therapeutic doses its sedative effect rather than a direct action may be responsible for muscle relaxation.

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3 Paracetamol
UNII 362O9ITL9D - ACETAMINOPHEN

Paracetamol is a medication used to treat pain and fever. It does appear to selectively inhibit COX activities in the brain, which may contribute to its ability to treat fever and pain.

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4 Caffeine
UNII 3G6A5W338E - CAFFEINE

Caffeine is structurally related to the methylxanthines theophylline and theobromine. Caffeine’s main action is as a CNS stimulant.

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Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: ZA Health Products Regulatory Authority Identifier(s): 28/2.9/0098

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