Local and loco-regional anaesthesia in dental surgery

Active Ingredient: Mepivacaine

Indication for Mepivacaine

Population group: only adults (18 - 65 years old)

For this indication, competent medicine agencies globally authorize below treatments:

220-300 mg once depending on patient's weight


Dosage regimens

Regimen A: Periodontal, 220 milligrams mepivacaine, one dose.

Regimen B: Periodontal, 264 milligrams mepivacaine, one dose.

Regimen C: Periodontal, 300 milligrams mepivacaine, one dose.

Detailed description

As occurs with all local anaesthetics, doses vary and depend on the area to be anaesthetised, on the vascularity of tissues, on the number of nerve segments to be blocked, on the individual tolerance and on the technique of anaesthesia. The lowest volume of injection leading to effective local anaesthesia should be administered. The necessary dosage must be determined on an individual basis.

Various volumes may be used provided that the total maximum recommended dose is not exceeded.

For a healthy adult of 70 kg, the maximum dose of mepivacaine administered by submucosal infiltration and/or nervous block should not exceed 4.4 mg/kg (0.15 ml/kg) of body weight with an absolute dose of 300 mg mepivacaine per session.

The maximum recommended doses are reported in the following table depending on the cartridge volume and on the patient’s weight.

 Equivalent in cartridge numbers
Weight (kg)Mepivacaine dose (mg)Volume (ml)1.8 ml

Due to the lack of clinical data, particular precaution should be used in order to administer the lowest dose leading to efficient anaesthesia in elderly people.

Dosage considerations

Infiltration and perineural use in oral cavity.

The rate of injection should not exceed 1 ml of solution per minute.

Active ingredient


Mepivacaine is an amide local anaesthetic. Mepivacaine has a rapid onset, a high potency of anaesthesia and a low toxicity.

Read more about Mepivacaine

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