Actidose-Aqua Advance Ref.[2640] Active ingredients: Charcoal activated

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2010  Publisher: Alliance Pharmaceuticals Ltd Avonbridge House 2 Bath Road Chippenham Wiltshire SN15 2BB UK

Pharmacodynamic properties

Activated charcoal has a high adsorptive capacity for a wide range of compounds including many of those which are most commonly encountered in deliberate and accidental poisoning. Substances adsorbed include the following:

  • Aspirin and other salicylates
  • Barbiturates
  • Benzodiazepines
  • Chlormethiazole
  • Chloroquine
  • Chlorpromazine and related phenothiazines
  • Clonidine
  • Cocaine and other stimulants
  • Digoxin and digitoxin
  • Ibuprofen
  • Mefenamic acid
  • Mianserin
  • Nicotine
  • Paracetamol
  • Paraquat
  • Phenelzine and other monoamine oxidase inhibitors
  • Phenytoin
  • Propranolol and other beta-blockers
  • Quinine
  • Theophylline
  • Zidovudine

Pharmacokinetic properties

Activated charcoal is not absorbed from the gastrointestinal tract or subject to any metabolic processes. It is eliminated in the faeces.

Preclinical safety data

Activated charcoal is essentially inert pharmacologically and it would therefore be expected to be virtually devoid of toxicity, other than any ill effects arising from mechanical obstruction of the gut, or, if inhaled, the lungs.

The excipients in the product are all well known and widely used in medicinal products and should not give rise to any toxicological problems.

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