Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2025 Publisher: Macarthys Laboratories Ltd, T/A Martindale Pharma, Bampton Road, Harold Hill, Romford, Essex, England, RM3 8UG
Adrenaline (Epinephrine) 1 mg/ml (1:1000) Solution for Injection may be used in the emergency treatment of
This medicinal product will be administered by a trained healthcare professional.
The intramuscular (IM) route is recommended by the EU Resuscitation Council as the most appropriate for most individuals who have to give adrenaline to treat an anaphylactic reaction. The patient should be monitored as soon as possible (pulse, blood pressure, ECG, pulse oximetry). This will help monitor the response to adrenaline.
The best site for IM injection is the anterolateral aspect of the middle third of the thigh.
The needle used for injection needs to be sufficiently long to ensure that the adrenaline is injected into muscle.
The subcutaneous route for adrenaline is not recommended for treatment of an anaphylactic reaction as it is less effective.
The usual dose is 0.5 mg (0.5ml of adrenaline 1mg/ml (1:1000)). If necessary, this dose may be repeated several times at 5-minute intervals according to blood pressure, pulse and respiratory function.
There are no specific dosage regimes for adrenaline injection in elderly patients. However, Adrenaline should be used with great caution in these patients who may be more susceptible to the cardiovascular side effects of adrenaline.
The following doses of Adrenaline (Epinephrine) 1 mg/ml (1:1000) Solution for Injection are recommended:
| Age | Dose |
|---|---|
| Over 12 years | 0.5 mg IM (0.5ml 1mg/ml (1:1000) solution) 0.3 mg IM (0.3ml 1mg/ml (1:1000) solution) if the child is small or pre-pubertal) |
| 6 - 12 years | 0.3 mg IM (0.3ml 1mg/ml (1:1000) solution) |
| 6 months - 6 years | 0.15 mg IM (0.15ml 1mg/ml (1:1000) solution) |
| Under 6 months | 0.01 mg/kg IM (0.01ml/kg 1mg/ml (1:1000) solution) |
If necessary, these doses may be repeated several times at 5-15 minutes intervals according to blood pressure, pulse and respiratory function.
A small volume syringe should be used.
Do not give Adrenaline (Epinephrine) 1mg/ml (1:1000) solution for injection intravenously.
Intravenous administration of adrenaline for anaphylaxis requires the use of a 1:10,000 adrenaline solution (please refer section 4.4 for intravenous use).
Over dosage or inadvertent intravenous administration of adrenaline may produce severe hypertension. Cerebral, cardiac or vascular accidents which could be potentially fatal may occur as a result (cerebral haemorrhage, dysrhythmias such as transient bradycardia followed by tachycardia that may result in arrhythmia, myocardial necrosis, acute pulmonary oedema, renal insufficiency).
The effects of adrenaline may be counteracted, depending on the condition of the patient, by administration of quick-acting vasodilators, of quick-acting alpha-adrenoreceptor blocking agents (e.g. phentolamine), or beta-adrenoreceptor blocking agents (e.g. propranolol). However, due to the short half-life of adrenaline, treatment with these medicines may not be necessary. In case of prolonged hypotensive reaction, administration of another vasopressive agent such as noradrenaline may be required.
2 years.
Keep ampoules in original carton in order to protect from light.
Do not freeze.
Do not store above 25ºC.
0.5, 1, 2, 5, 10 ml in type 1 colourless neutral OPC (one point cut) glass ampoules.
Fusion sealed.
Packed into cartons of 10 ampoules.
Not all pack sizes may be marketed.
For single use only. If only part used, discard the remaining solution.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
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