ANTHISAN BITE AND STING Cream Ref.[9338] Active ingredients: Mepyramine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2020  Publisher: Aventis Pharma Limited, trading as Sanofi, 410 Thames Valley Park Drive, Reading, Berkshire, RG6 1PT, United Kingdom

Product name and form

Anthisan Bite and Sting 2% w/w Cream.

Pharmaceutical Form

A smooth off-white cream.

Qualitative and quantitative composition

Mepyramine Maleate 2% w/w.

Also contains:

Castor oil 23,60% w/w
Ceto-stearyl alcohol 13,80% w/w
Propylene glycol 600 monostearate 4,90% w/w
Methyl hydroxybenzoate 0,20% w/w

For a full list of excipients, see section 6.1.

Active Ingredient Description
Mepyramine

Mepyramine is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. Mepyramine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Mepyramine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of mepyramine occur at the subcortical level of the CNS. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

List of Excipients

Ceto-stearyl alcohol
Polyethylene glycol 600 monostearate
Castor oil
Methyl hydroxybenzoate
Foin coupe (fragrance)
Silicone antifoam
Purified water

Pack sizes and marketing

Collapsible aluminium tube with extended nozzle and polyethylene screw cap containing 20g cream.

Marketing authorization holder

Aventis Pharma Limited, trading as Sanofi, 410 Thames Valley Park Drive, Reading, Berkshire, RG6 1PT, United Kingdom

Marketing authorization dates and numbers

PL 04425/0275

Date of first authorisation: 7 June 2000
Date of latest renewal: 2 September 2005

Drugs

Drug Countries
ANTHISAN Ireland, Malta, New Zealand, United Kingdom

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