Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Mercury Pharmaceuticals Ltd, Capital House, 85 King William Street, London EC4N 7BL, UK
For use in diabetes insipidus, when this is not of nephrogenic origin and control of bleeding from oesophageal varices.
A dose of 0.25ml to 1ml (5 to 20 units) by subcutaneous or intramuscular injection every four hours.
For the initial control of variceal bleeding Argipressin should be given intravenously. Argipressin, 20 units diluted in 100ml dextrose 5% w/v may be infused over a 15 minute period.
As for adults, no clinical or pharmacokinetic data specific to this age group are available. However, the drug has been successfully used at normal dosage in the elderly.
Not recommended in children below 18 years.
Subcutaneous, intravenous or intramuscular injection.
If water intoxication occurs, no fluids should be given. In severe cases, small amounts of hypertonic saline may be administered. Urea and mannitol infusions may be helpful in cases of cerebral oedema. If a patient should experience anginal pain after administration of Argipressin, amyl nitrite by inhalation or glyceryl trinitrate sublingually, may be given.
Shelf life: 24 months.
Store in a refrigerator (2°C and 8°C). Do not freeze.
Keep the ampoules in the outer carton in order to protect from light.
Clear OPC/blue glass ampoules with white and blue rings above the OPC.
The white and blue rings are for product identification and should not be taken as break rings. The ampoules should be open cut at the OPC
Available in packs of 10 x1ml ampoules.
For single use only.
If only part used, discard the remaining solution.
No special requirements for disposal.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
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