Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2017 Publisher: Wockhardt UK Ltd, Ash Road North, Wrexham LL13 9UF, UK
Pharmacotherapeutic group: Antibacterials for systemic use. Third-generation cephalosporins
ATC code: J01DD02
Ceftazidime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.
For cephalosporins, the most important pharmacokinetic-pharmacodynamic index correlating with in vivo efficacy has been shown to be the percentage of the dosing interval that the unbound concentration remains above the minimum inhibitory concentration (MIC) of ceftazidime for individual target species (i.e. %T>MIC).
Bacterial resistance to ceftazidime may be due to one or more of the following mechanisms:
Minimum inhibitory concentration (MIC) breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) are as follows:
| Organism | Breakpoints (mg/L) | ||
|---|---|---|---|
| S | I | R | |
| Enterobacteriaceae | ≤1 | 2-4 | >4 |
| Pseudomonas aeruginosa | ≤81 | - | >8 |
| Non-species related breakpoints^2^ | ≤4 | 8 | >8 |
S=susceptible, I=intermediate, R=resistant.
1 The breakpoints relate to high dose therapy (2g x 3).
2 Non-species related breakpoints have been determined mainly on the basis of PK/PD data and are independent of MIC distributions of specific species. They are for use only for species not mentioned in the table or footnotes.
The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of ceftazidime in at least some types of infections is questionable.
Gram-positive aerobes:
Streptococcus pyogenes
Streptococcus agalactiae
Gram-negative aerobes:
Citrobacter koseri
Haemophilus influenzae
Moraxella catarrhalis
Neisseria meningitidis
Pasteurella multocida
Proteus mirabilis
Proteus spp. (other)
Providencia spp.
Gram-negative aerobes:
Acinetobacter baumannii+
Burkholderia cepacia
Citrobacter freundii
Enterobacter aerogenes
Enterobacter cloacae
Escherichia coli
Klebsiella pneumoniae
Klebsiella spp. (other)
Pseudomonas aeruginosa
Serratia spp.
Morganella morganii
Gram-positive aerobes:
Staphylococcus aureus £
Streptococcus pneumoniae ££
Viridans group streptococcus
Gram-positive anaerobes:
Clostridium perfringens
Peptostreptococcus spp.
Gram-negative anaerobes:
Fusobacterium spp.
Gram-positive aerobes:
Enterococcus spp including Enterococcus faecalis and Enterococcus faecium
Listeria spp.
Gram-positive anaerobes:
Clostridium difficile
Gram-negative anaerobes:
Bacteroides spp. (many strains of Bacteroides fragilis are resistant).
Others:
Chlamydia spp.
Mycoplasma spp.
Legionella spp.
£ S. aureus that is methicillin-susceptible are considered to have inherent low susceptibility to ceftazidime. All methicillin-resistant S. aureus are resistant to ceftazidime.
££ S. pneumoniae that demonstrate intermediate suseptibility or are resistant to penicillin can be expected to demonstrate at least reduced susceptibility to ceftazidime.
+ High rates of resistance have been observed in one or more areas/countries/regions within the EU.
After intramuscular administration of 500 mg and 1 g of ceftazidime, peak plasma levels of 18 and 37 mg/l, respectively, are achieved rapidly. Five minutes after intravenous bolus injection of 500 mg, 1 g or 2 g, plasma levels are 46, 87 and 170 mg/l, respectively. The kinetics of ceftazidime are linear within the single dose range of 0.5 to 2 g following intravenous or intramuscular dosing.
The serum protein binding of ceftazidime is low at about 10%. Concentrations in excess of the MIC for common pathogens can be achieved in tissues such as bone, heart, bile, sputum, aqueous humour, synovial, pleural and peritoneal fluids. Ceftazidime crosses the placenta readily, and is excreted in the breast milk. Penetration of the intact blood-brain barrier is poor, resulting in low levels of ceftazidime in the CSF in the absence of inflammation. However, concentrations of 4 to 20 mg/l or more are achieved in the CSF when the meninges are inflamed.
Ceftazidime is not metabolised.
After parenteral administration plasma levels decrease with a half-life of about 2h. Ceftazidime is excreted unchanged into the urine by glomerular filtration; approximately 80 to 90% of the dose is recovered in the urine within 24 h. Less than 1% is excreted via the bile.
Elimination of ceftazidime is decreased in patients with impaired renal function and the dose should be reduced (see section 4.2).
The presence of mild to moderate hepatic dysfunction had no effect on the pharmacokinetics of ceftazidime in individuals administered 2 g intravenously every 8 hours for 5 days, provided renal function was not impaired (see section 4.2).
The reduced clearance observed in elderly patients was primarily due to age-related decrease in renal clearance of ceftazidime. The mean elimination half-life ranged from 3.5 to 4 hours following single or 7 days repeat BID dosing of 2 g IV bolus injections in elderly patients 80 years or older.
The half-life of ceftazidime is prolonged in preterm and term neonates by 4.5 to 7.5 hours after doses of 25 to 30 mg/kg. However, by the age of 2 months the half-life is within the range for adults.
Non-clinical data reveal no special hazard for humans based on studies of safety pharmacology, repeat dose toxicity, genotoxicity, toxicity to reproduction. Carcinogenicity studies have not been performed with ceftazidime.
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