COBALIN Injection Ref.[7149] Active ingredients: Vitamin B12

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2018  Publisher: Amdipharm UK Limited, Capital House, 85 King William Street, London EC4N 7BL, UK

Therapeutic indications

Treatment of Addisonian pernicious anaemia.

Prophylaxis and treatment of other macrocytic anaemias due to vitamin B12 deficiency.

Treatment of tobacco amblyopia.

Treatment of Leber’s atrophy.

Posology and method of administration

Posology

The following dosages are suitable for children and adults.

Addisonian pernicious anaemia and other macrocytic anaemias without neurological involvement:

Initially: 250 micrograms to 1000 micrograms intramuscularly on alternate days for one or two weeks then 250 micrograms weekly until blood count is normal.

Maintenance: 1000 micrograms every two or three months.

Addisonian pernicious anaemia and other macrocytic anaemias with neurological involvement:

Initially: 1000 micrograms on alternate days as long as improvement continues.

Maintenance: 1000 micrograms every two months.

Prophylaxis of macrocytic anaemias associated with vitamin B12 deficiency resulting from gastrectomy, ileal resection, certain ma/absorption states and vegetarianism:

1000 micrograms every two or three months.

Tobacco amblyopia and Leber’s optic atrophy:

Initially: 1000 micrograms daily by intramuscular injection for two weeks then twice weekly as long as improvement is maintained.

Maintenance: 1000 micrograms every three months or as required.

Overdose

Treatment is unlikely to be needed in case of overdose.

Shelf life

Shelf life: 36 months.

Special precautions for storage

Protect from light. Store below 25°C.

Nature and contents of container

This medicine is supplied in clear 1ml Type I glass ampoules in cartons of 5 or 10.

Special precautions for disposal and other handling

None stated.

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