EPIDYOLEX Oral solution Ref.[27759] Active ingredients: Cannabidiol

Source: European Medicines Agency (EU)  Revision Year: 2025  Publisher: Jazz Pharmaceuticals Ireland Ltd, 5 th Floor, Waterloo Exchange, Waterloo Road, Dublin 4, D04 E5W7, Ireland

Product name and form

Epidyolex 100 mg/ml oral solution.

Pharmaceutical Form

Oral solution.

Clear, colourless to yellow solution.

Qualitative and quantitative composition

Each ml of oral solution contains 100 mg cannabidiol.

Excipients with known effect:

Each ml of solution contains:

79 mg anhydrous ethanol
736 mg refined sesame oil
0.0003 mg benzyl alcohol

For the full list of excipients, see section 6.1.

Active Ingredient

Cannabidiol is indicated for the treatment of seizures associated with Lennox‑Gastaut syndrome (LGS), Dravet syndrome (DS), or tuberous sclerosis complex (TSC) in patients 1 year of age and older.

List of Excipients

Refined sesame oil
Anhydrous ethanol
Sucralose (E955)
Strawberry flavour (including benzyl alcohol)

Pack sizes and marketing

Amber glass bottle (type III) with a child-resistant and tamper-evident screw cap (polypropylene).

The following pack sizes are available for Epidyolex 100 mg/ml oral solution:

100 ml (1 × 100 ml bottle) with 2 × 5 ml and 2 × 1 ml calibrated oral dosing syringes (HDPE plunger and Polypropylene barrel) and two bottle adaptors (LDPE).

300 ml (3 × 100 ml bottles) with 2 × 5 ml and 2 × 1 ml calibrated oral dosing syringes (HDPE plunger and Polypropylene barrel) and three bottle adaptors (LDPE).

The 5 ml syringes are graduated in 0.1 ml increments and the 1 ml syringes are graduated in 0.05 ml increments.

Not all pack sizes may be marketed.

Marketing authorization holder

Jazz Pharmaceuticals Ireland Ltd, 5th Floor, Waterloo Exchange, Waterloo Road, Dublin 4, D04 E5W7, Ireland

Marketing authorization dates and numbers

EU/1/19/1389/001
EU/1/19/1389/002

Date of first authorisation: 19 September 2019
Date of latest renewal: 26 July 2024

Drugs

Drug Countries
EPIDYOLEX Austria, Australia, Estonia, Finland, France, Croatia, Ireland, Italy, Lithuania, Poland, Romania, United Kingdom

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