Source: Registered Drug Product Database (NG) Revision Year: 2021 Publisher: EIPICO
FLUMOX is a combination of two bactericidal penicillins: amoxycilin (broad-spectrum penicillin) and flucloxacillin (penicillinase-resistant penicillin), to produce a wider spectrum of activity. Flucloxacillin exerts a bactericidal action on penicillinase-producing microorganism including most staphylococci. This combination exhibits bactericidal activity against a wide range of Gram-positive and Gram-negative microorganisms including penicillinase and non penicillinase-producing Staphylococci, Streptococcus pyogenes, pneumoniae, and faecalis, Corynebacterillm diphtheriae, Clostridia spp., Bacillus anthracis; H. influenzae, Moraxella (Branhamella) catarrhalis, N. gonorrheae and meningitidis, E. coli, Proteus mirabilis, Salmonella, Bordetella pertussis. and Bacteroides melaninogenicus.
Both amoxycillin and flucloxacillin are acid-stable and are well absorbed after oral administration. Amoxycillin is more rapidly absorbed than ampicillin producing higher plasma concentrations than those obtained with the same dose of ampicillin. Peak plasma concentrations of amoxycillin and flucloxacillin are achieved in about 1 to 2 hours after oral administration; and in about 30 minutes after parenteral administration. FLUMOX is widely distributed in body tissues and fluids. Amoxycillin and flucloxacillin are metabolized to a limited extent, and the unchanged drugs and metabolites are excreted in the urine by glomerular filtration and renal tubular secretion and also in bile.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.