Source: Medicines & Healthcare Products Regulatory Agency (GB) | Revision Year: 2019 | Publisher: Piramal Critical Care Limited, Suite 4, Ground Floor, Heathrow Boulevard East Wing, 280 Bath Road, West Drayton, UB7 0DQ, United Kingdom
ISOFLURANE 100% Inhalation vapour, liquid.
Inhalation vapour, liquid.
Isoflurane, 100% active.
Isoflurane is a general inhalational anaesthetic for use in induction and maintenance. Isoflurane provides rapid induction of anaesthesia and also rapid recovery.
Isoflurane is a fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.
Amber glass Type III nominal 100 ml or 250 ml bottle with black screw cap and polyethylene cone.
Piramal Critical Care Limited, Suite 4, Ground Floor, Heathrow Boulevard – East Wing, 280 Bath Road, West Drayton, UB7 0DQ, United Kingdom
1 February 1999 / 16th April 2002
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