JIDEYTRO Film-coated tablet Ref.[116775] Active ingredients:

Zidesamtinib is a kinase inhibitor. The molecular formula for zidesamtinib is C22H22FN7O and the molecular weight is 419.46 Daltons. The chemical name is (R)3-Ethyl-16-fluoro-10-methyl-19-methyl-20-oxa 3,4,9,10,11,23-hexaazapentacyclo[19.3.1.0^2,6.0^8,12.0^13,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22- decaen-22-ylamine. The chemical structure of zidesamtinib is as follows:

Zidesamtinib is a white to tan powder with a pKa of 4.89. The aqueous solubility of zidesamtinib at 37°C is pH dependent, decreasing from 25 mg/mL at pH 2.5 to less than 0.1 mg/mL at pH 7.9. The log of the distribution coefficient (octanol/water) at pH 7.4 is 3.01.

JIDEYTRO (zidesamtinib) tablets for oral use are supplied as 25 mg and 100 mg dosage strengths. JIDEYTRO tablets, 25 mg are film-coated, oblong, pink tablets, debossed with "25" on one side and "ZDS" on the other side of the tablet. JIDEYTRO tablets, 100 mg are film-coated, oblong, yellow tablets, debossed with "100" on one side and "ZDS" on the other side of the tablet. Inactive ingredients in the tablet core are hydroxypropyl cellulose, magnesium stearate, mannitol, microcrystalline cellulose and sodium starch glycolate.